{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:08:59Z","timestamp":1791306539589,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Population\u2010based anthropometric evaluation of malformed newborns is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate malformed newborns' foetal growth using the ICD 10 malformations' classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A study including 33,769 newborns (14,857 malformed and 18,912 nonmalformed), selected from 678,840 births from nine South American countries, period 2010\u20132018, was conducted. Prevalence of severe small and small for gestational age was calculated for malformed and nonmalformed newborns classified by preterm birth categories. Prevalence and relative risk (RR) with its 95% confidence interval (CI) were calculated. The associations between anthropometric phenotypes and congenital malformations were evaluated with generalized linear models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of preterm and term severe small and small for gestational age newborns was higher in malformed than that in nonmalformed neonates. For grouped ICD 10 malformations categories, the RR for severe small for gestational age was 2.88 (95% CI 2.51, 3.30) and 2.10 (95% CI 1.92, 2.30) for small for gestational age. For at\u2010term and preterm malformed newborns, the RR for severe small for gestational age was 2.21 (95% CI 1.87, 2.61) and 3.21 (95% CI 2.52, 4.10), respectively; for small for gestational age, the RR was 2.31 (95% CI 2.11, 2.53) for at\u2010term newborns and 2.58 (95% CI 2.16, 3.08) for preterm ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence and relative risk of severe small and small for gestational age vary according to the group of malformations and gestational age; they increase in congenital malformations of the nervous, respiratory and digestive systems, and in chromosomal abnormalities and are lower for malformations of eye, ear, face and neck and cleft lip and palate. Foetal growth considered together with malformed newborns' gestational age would allow for inferring different risks of morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12843","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:49:39Z","timestamp":1645454979000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal anthropometry of malformed newborns: A large South American population\u2010based study"],"prefix":"10.1111","volume":"36","author":[{"given":"Silvina","family":"Heisecke","sequence":"first","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) Universidad Nacional de Jujuy\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (UNJu\u2010CONICET)  San Salvador de Jujuy Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) Universidad Nacional de Jujuy\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (UNJu\u2010CONICET)  San Salvador de Jujuy Argentina"},{"name":"Instituto de Biolog\u00eda de la Altura Universidad Nacional de Jujuy  San Salvador de Jujuy Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Instituto de Ecorregiones Andinas (INECOA) Universidad Nacional de Jujuy\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (UNJu\u2010CONICET)  San Salvador de Jujuy Argentina"},{"name":"Instituto de Estudios Celulares, Gen\u00e9ticos y Moleculares (ICeGeM) Universidad Nacional de Jujuy  San Salvador de Jujuy Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Bronberg","sequence":"additional","affiliation":[{"name":"\u00c1rea de Gen\u00e9tica M\u00e9dica y Poblacional Hospital Ramos Mej\u00eda  Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ratowiecki","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC) Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-5447","authenticated-orcid":false,"given":"Jorge S.","family":"L\u00f3pez Camelo","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC) Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"},{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP) Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC\u2010CONICET)  Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 E.","family":"Dipierri","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda de la Altura Universidad Nacional de Jujuy  San Salvador de Jujuy Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"ChristiansonA HowsonCP ModellB.Global report on birth defects. March of Dimes Birth Defects Foundation. White Plains New York. Available:https:\/\/www.marchofdimes.org\/materials\/global\u2010report\u2010on\u2010birth\u2010defects\u2010the\u2010hidden\u2010toll\u2010of\u2010\u2010d2unzZI5_VWOaLZnw6iHcx7hbpMWtWzTuIOU3DabcVY.pdf. Last Accessed April 29 2021."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1996)13:5<469::AID-GEPI3>3.0.CO;2-Y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23481"},{"key":"e_1_2_11_5_1","unstructured":"WHO.Birth defects report by the secretariat. Sixty\u2010third world health assembly.2010.https:\/\/www.who.int\/westernpacific\/health\u2010topics\/congenital\u2010anomalies. Last accessed April 29 2021."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90690-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.82.1.83"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2014.03.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.089"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174419000369"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1438"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.096214"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000345"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13112"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00384-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.564"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70006-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002717"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2018.03.007"},{"issue":"6","key":"e_1_2_11_21_1","first-page":"547","article-title":"Prevalence of underweight and small for gestational age in Argentina: comparison between the INTERGROWTH\u201021st standard and an Argentine reference","volume":"115","author":"Revollo GB","year":"2017","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JCN.0000287028.87746.11"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/1363849031000097817"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2015.11.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000275264.78506.63"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.180"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-008-0348-y"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0507-2"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080776"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356568"},{"key":"e_1_2_11_31_1","unstructured":"https:\/\/icd.who.int\/browse10\/2010\/en#\/XVII. Last accessed April 29 2021."},{"key":"e_1_2_11_32_1","unstructured":"https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/preterm\u2010birth. Last accessed April 29 2021."},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429258589"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v023.i07"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014468900000532"},{"key":"e_1_2_11_36_1","unstructured":"MuMInBK.Multi\u2010model inference. R package version 1.43.10.2019. Availablehttps:\/\/CRAN.R\u2010project.org\/package=MuMIn. Last accessed April 29 2021."},{"key":"e_1_2_11_37_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2019"},{"issue":"3","key":"e_1_2_11_38_1","first-page":"203","article-title":"Analysis of infant mortality from congenital malformations in Argentina during the 2002\u20132006 period","volume":"107","author":"Bronberg R","year":"2009","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-013-0170-0"},{"issue":"5","key":"e_1_2_11_40_1","first-page":"380","article-title":"Infant mortality from congenital malformations in Chile: temporal and spatial analysis, 1997\u20132011","volume":"38","author":"Dipierri JE","year":"2015","journal-title":"Rev Panam Salud P\u00fablica"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60993-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.17795\/jjhr.36171"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1881"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ppe.12843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:26:22Z","timestamp":1692843982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppe.12843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/ppe.12843"],"URL":"https:\/\/doi.org\/10.1111\/ppe.12843","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"2021-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}