{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T06:22:06Z","timestamp":1788070926794,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["733280"],"award-info":[{"award-number":["733280"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preterm birth is associated with adverse health and developmental sequelae that impose a burden on finite resources and significant challenges for individuals, families and societies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate economic outcomes at age 11 associated with extremely preterm birth using evidence from a whole population study (EPICure2 study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised a sample of children born at \u226426 completed weeks of gestation during 2006 in England (<jats:italic>n<\/jats:italic>\u00a0=\u00a0200) and a comparison group of classmates born at term (<jats:italic>n<\/jats:italic>\u00a0=\u00a0143). Societal costs were estimated using parent and teacher reports of service utilisation, and valuations of work losses and additional care costs to families. Utility scores for the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) were generated using UK and Canadian value sets. Generalised linear regression was used to estimate the impact of extremely preterm birth on societal costs and utility scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unadjusted mean societal costs that excluded provision of special educational support in mainstream schools during the 11th year after birth were \u00a36536 for the extremely preterm group and \u00a33275 for their classmates, generating a difference of \u00a33262 (95% confidence interval [CI] \u00a31912, \u00a35543). The mean adjusted cost difference was \u00a32916 (95% CI \u00a31609, \u00a34224), including special educational needs provision in mainstream schools increased the adjusted cost difference to \u00a34772 (95% CI \u00a33166, \u00a36378). Compared with birth at term, extremely preterm birth generated mean\u2010adjusted utility decrements ranging from 0.13 (95% CI 0.09, 0.18) based on the UK HUI2 statistical inference tariff to 0.28 (95% CI 0.18, 0.37) based on the Canadian HUI3 tariff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The adverse economic impact of extremely preterm birth persists into late childhood. Further longitudinal studies conducted from multiple perspectives are needed to understand the magnitude, trajectory and underpinning mechanisms of economic outcomes following extremely preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12906","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T16:38:04Z","timestamp":1657730284000},"page":"696-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Economic costs and health utility values associated with extremely preterm birth: Evidence from the <scp>EPICure2<\/scp> cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-9125","authenticated-orcid":false,"given":"Felix","family":"Achana","sequence":"first","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"},{"name":"Division of Health Sciences, Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Ni","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"},{"name":"Department of Psychology University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Marlow","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Wolke","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Warwick Medical School University of Warwick  Coventry UK"},{"name":"Department of Psychology University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Khan","sequence":"additional","affiliation":[{"name":"Warwick Clinical Trials Unit University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Petrou","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.02.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13195"},{"key":"e_1_2_11_4_1","volume-title":"Born too soon: the global action report on preterm birth","author":"WHO","year":"2012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7961"},{"key":"e_1_2_11_6_1","unstructured":"Office for National Statistics (ONS).Birth characteristics in England and Wales:2019.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/livebirths\/bulletins\/birthcharacteristicsinenglandandwales\/2019. 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