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This lack of enriched pregnancy and birth data led to the initiation of the Swedish Stockholm\u2013Gotland Perinatal Cohort (SGPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the strengths of the SGPC, as well as the unique research questions that can be addressed using this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>The SGPC is a prospectively collected, population\u2010based cohort that includes all births (from 22 completed gestational weeks onwards) between 1 January 2008 and 15 June 2020 in the Stockholm and Gotland regions of Sweden (335,153 singleton and 11,025 multiple pregnancies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Descriptive study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SGPC is based on the electronic medical records of women and their infants. The medical record system is used for all antenatal clinic visits and admissions, delivery and neonatal admissions, as well as postpartum clinical visits. SGPC has been further enriched with data linkages to 10 Swedish National Health Care and Quality Registers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Preliminary Results<\/jats:title><jats:p>In contrast to other reproductive and perinatal databases available in Sweden, including the Medical Birth Register and the Pregnancy Register, SGPC contains highly detailed medical record data, including time\u2010varying serial measurements for physiological parameters throughout pregnancy, delivery, and postpartum, for both mother and infant. These strengths have enabled studies that were previously inconceivable; the effects of serial measurements of pregnancy weight gain, changes in haemoglobin counts and blood pressure during pregnancy, fetal weight estimations by ultrasound, duration of stages and phases of labour, cervical dilatation and oxytocin use during delivery, and constructing reference curves for umbilical cord pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SGPC\u2014with its rich content, repeated measurements and linkages to numerous health care and quality registers\u2014is a unique cohort that enables high\u2010quality perinatal studies that would otherwise not be 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