{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:22:14Z","timestamp":1790083334933,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1172978"],"award-info":[{"award-number":["APP1172978"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advances in screening and diagnostics have changed the way in which we identify and diagnose congenital anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine changes in rates of prenatal diagnosis of congenital anomalies over time and by demographic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a population\u2010based retrospective cohort study of all children born in Western Australia between 1980 and 2020 and diagnosed with a congenital anomaly. Age at diagnosis (prenatal, neonatal, infancy, early childhood or childhood) prevalence (all\u2010type and type\u2010specific), and prevalence ratios (PR) were calculated. We fit joinpoint regression models to describe the average annual percentage change (APC) in prenatal diagnosis over time, and log\u2010binomial regression models to estimate the association between prenatal diagnosis and demographic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prenatal diagnosis prevalence between the first (1980\u20131989: 28.3 per 10,000 births) and last (2005\u20132014: 156.1 per 10,000 births) decades of the study increased 5.5\u2010fold (95% confidence interval [CI] 5.0, 5.9). Substantial increases were observed for cardiovascular (PR 10.7, 95% CI 8.0, 14.6), urogenital (PR 10.5, 95% CI: 8.7, 12.6) and chromosomal anomalies (PR 7.0, 95% CI 5.9, 8.3). Prenatal diagnosis was positively associated with the birth year (adjusted risk ratio [RR] 1.04, 95% CI 1.03, 1.04), advanced maternal age (RR 1.14, 95% CI 1.11, 1.18), multiple anomalies (RR 2.86, 95% CI 2.77, 2.96) and major anomalies (RR 3.75, 95% CI 3.36, 4.19), and inversely associated with remoteness (RR 0.89, 95% CI: 0.83, 0.95) and Aboriginality (RR 0.90, 95% CI 0.83, 0.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increases in prenatal diagnosis of congenital anomalies were observed in Western Australia from 1980 to 2020, reflecting advances in screening. Prenatal diagnosis was less common in remote regions and in Aboriginal children, strengthening calls for increased provision of antenatal care services for these populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12983","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T04:11:16Z","timestamp":1683259876000},"page":"596-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Trends in prenatal diagnosis of congenital anomalies in Western Australia between 1980 and 2020: A population\u2010based study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-0551","authenticated-orcid":false,"given":"Cassandra","family":"MacArthur","sequence":"first","affiliation":[{"name":"School of Population and Global Health The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2031","authenticated-orcid":false,"given":"Michele","family":"Hansen","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-9553","authenticated-orcid":false,"given":"Gareth","family":"Baynam","sequence":"additional","affiliation":[{"name":"Western Australian Register of Developmental Anomalies King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"Faculty of Health and Medicine, Institute and Division of Paediatrics University of Western Australia  Crawley Western Australia Australia"},{"name":"Rare Care, Clinical Centre of Expertise for Rare and Undiagnosed Diseases Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-2756","authenticated-orcid":false,"given":"Carol","family":"Bower","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-2216","authenticated-orcid":false,"given":"Erin","family":"Kelty","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Management of Birth Defects and Haemoglobin Disorders: Report of a Joint WHO\u2010March of Dimes Meeting, Geneva, Switzerland, 17\u201319 May 2006","author":"World Health 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