{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:38:12Z","timestamp":1787765892818,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid weight gain during infancy is a strong predictor of childhood obesity and is affected by genetic and environmental factors. Identifying ages with low heritability will allow for targeted interventions that might be able to prevent the adverse effects of childhood obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of the study is to estimate the heritability of weight gain from birth to defined ages during infancy, as well as during 6\u2010month periods from birth to 18\u2009months of age. We address this by leveraging large\u2010scale computerised anthropometric data from the state\u2010run network of well\u2010baby clinics in Israel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a population\u2010based twin study. We extracted weight measurements recorded between birth to 24\u2009months from well\u2010baby clinics for 9388 twin pairs born in Israel between 2011 and 2015. The reported sexes of the twins were used as a proxy for their zygosity status. We estimated the heritability of the weight z\u2010score change from birth to specific ages and during particular periods in infancy. To assess the validity of the results, we repeated the analysis in a sub\u2010cohort of twin pairs with complete weight measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the first 2\u2009years of life, heritability was lowest for birthweight (). Heritability for weight gain since birth was highest at 4\u2009months (), and then gradually decreased until age 18\u2009months (). Estimating the heritability in 6\u2010month intervals from birth to 18\u2009months, heritability was highest during the 6\u201312\u2010month interval (), and was substantially lower during the subsequent 12\u201318\u2010month interval ().<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heritability of weight gain decreases substantially in the second year of life, suggesting that this period could be an appropriate time for interventions for infants who are at an increased risk of childhood obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12991","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:20:14Z","timestamp":1686194414000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The heritability of weight gain in infancy: A population\u2010based twin study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-6102","authenticated-orcid":false,"given":"Masha","family":"Krichevski","sequence":"first","affiliation":[{"name":"Braun School of Public Health and Community Medicine The Hebrew University of Jerusalem \u2010 Hadassah  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Calderon\u2010Margalit","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine The Hebrew University of Jerusalem \u2010 Hadassah  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Carmi","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine The Hebrew University of Jerusalem \u2010 Hadassah  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-3909","authenticated-orcid":false,"given":"Raanan","family":"Raz","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine The Hebrew University of Jerusalem \u2010 Hadassah  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1353\/foc.2006.0001"},{"key":"e_1_2_10_3_1","volume-title":"The Epidemiological Burden of Obesity in Childhood: A Worldwide Epidemic Requiring Urgent Action","author":"Di Cesare M","year":"2019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12334"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.154628"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4691-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/108187"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0560-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29867"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.183"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12632"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2005.00183.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0757"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20120107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.29.135"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08046"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20660"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030153"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.11.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.012757"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019918"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1375\/1369052042663805"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039901"},{"key":"e_1_2_10_24_1","unstructured":"State Controller of Israel \u2013 Annual Report 64c \u2013 Ministry of Health \u2013 Well Mother and Baby Clinics \u2013 2014;2014. 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