{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:56:48Z","timestamp":1747187808982,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010dose aspirin prophylaxis is recommended for women at risk of preeclampsia. Capturing aspirin prophylaxis within administrative databases can be challenging since it is an over\u2010the\u2010counter medication. The Better Outcome Registry and Network (BORN) database, a perinatal health registry in Ontario, Canada, includes a formal variable that captures aspirin prophylaxis for preeclampsia. This variable has not been formally validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the accuracy of the aspirin prophylaxis variable in the BORN database against an electronic medical record (EMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This validation study comprised 200 randomly selected women who had a livebirth at St. Michael's Hospital (SMH) in Toronto, Ontario, from January 2018 to July 2022. Recorded aspirin prophylaxis in pregnancy and maternal sociodemographic characteristics were independently extracted by two abstractors. Accuracy of aspirin prophylaxis use in the BORN database was compared to that in the SMH EMR, expressed as sensitivity, specificity, positive (PPV) and negative predictive values (NPV), Cohen's kappa (<jats:italic>\u03ba<\/jats:italic>), and overall percent agreement, with 95% confidence intervals (CI). Sensitivity analyses were performed to account for missing or unclear aspirin prophylaxis use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 200 women, 24 (12.0%) received aspirin prophylaxis \u2013 12.5% within the SMH EMR and 8.0% in the BORN database. Women using aspirin were older (37.0 vs 33.0\u2009years) and had higher median gravidity (3 vs. 2). Sensitivity and specificity of the BORN aspirin prophylaxis variable were 62.5% (95% CI 40.6, 81.2) and 100.0% (95% CI 97.3, 100.0), respectively. The corresponding positive and negative predictive values were 100.0% (95% CI 78.2, 100.0), and 93.8% (95% CI 88.6, 97.1), respectively. Cohen's <jats:italic>\u03ba<\/jats:italic> was 0.74 (95% CI 0.58, 0.90), and overall percent agreement was 94.4% (95% CI 87.1, 100.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aspirin use within the BORN database, based on a standard variable field, appears accurate enough for the potential use in epidemiological studies of aspirin prophylaxis for preeclampsia or as a covariate in related studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.13003","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:46:43Z","timestamp":1692568003000},"page":"515-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of aspirin prophylaxis for preeclampsia prevention documentation within a large administrative dataset"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-8755","authenticated-orcid":false,"given":"Lauren S.","family":"Tailor","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"The Hospital for Sick Children Child Health Evaluative Sciences  Ontario Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee G.","family":"Fajardo","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Child Health Evaluative Sciences  Ontario Toronto Canada"},{"name":"Faculty of Science and the Schulich School of Medicine and Dentistry Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel G.","family":"Ray","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Child Health Evaluative Sciences  Ontario Toronto Canada"},{"name":"Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynaecology, St Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Malham\u00e9","sequence":"additional","affiliation":[{"name":"McGill University, McGill University Health Centre  Quebec Montreal Canada"},{"name":"Research Institute of the McGill University Health Centre Centre for Outcomes Research and Evaluation  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-7854","authenticated-orcid":false,"given":"Sonia M.","family":"Grandi","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"The Hospital for Sick Children Child Health Evaluative Sciences  Ontario Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Public Health Agency of Canada.Maternal Hypertension in Canada. [Internet] Ottawa: Government of Canada2014; Available from:https:\/\/www.canada.ca\/en\/publichealth\/services\/publications\/healthy\u2010living\/maternal\u2010hypertension\u2010canada.html"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2019.02.014"},{"volume-title":"High blood pressure during pregnancy","year":"2023","author":"CDC","key":"e_1_2_11_4_1"},{"volume-title":"Delivery hospitalizations involving preeclampsia and eclampsia, 2005\u20102014","year":"2017","author":"Fingar KR","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12802"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000213"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.11.1357"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06561-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092681"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.05.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac669"},{"key":"e_1_2_11_13_1","unstructured":"American College of Obstetricians and Gynecologists.Low\u2010dose aspirin use for the prevention of preeclampsia and related morbidity and mortality. 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