{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:59:44Z","timestamp":1768035584407,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current guidelines recommend HCV screening by 18\u2009months of age for those exposed to HCV in utero; yet, screening occurs in the minority of children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the association between maternal neighbourhood\u2010level social determinants of health (SDOH) and paediatric HCV screening in the general population in a publicly funded healthcare system in Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study using administrative healthcare data held at ICES. Children born to individuals positive for HCV RNA in pregnancy from 2000 to 2016 were identified and followed for 2\u2009years. Major SDOH were identified, and the primary outcome was HCV screening in exposed children (HCV antibody and\/or RNA). Associations between SDOH and HCV screening were determined using multivariate Poisson regression models adjusting for confounding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1780 children born to persons with +HCV RNA were identified, and 29% (<jats:italic>n<\/jats:italic>\u2009=\u2009516) were screened for HCV by age two. Most mothers resided in the lowest income quintile (42%), and most vulnerable quintiles for material deprivation (41%), housing instability (38%) and ethnic diversity (26%) with 11% living in rural locations. After adjustment for confounding, maternal rural residence (risk ratio [RR] 0.82, 95% confidence interval [CI] 0.62, 1.07) and living in the highest dependency quintile (RR 0.83, 95% CI 0.65, 1.07) were the SDOH most associated with paediatric HCV screening. Younger maternal age (RR 0.98 per 1\u2010year increase, 95% CI 0.97, 0.99), HIV co\u2010infection (RR 1.69, 95% CI 1.16, 2.48) and GI specialist involvement (RR 1.18, 95% CI 1.00, 1.39) were associated with higher probabilities of screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among children exposed to HCV during pregnancy, rural residences and living in highly dependent neighbourhoods showed a potential association with a lower probability of HCV screening by the age of 2. Future work evaluating barriers to paediatric HCV screening among rural residing and dependent residents is needed to enhance the screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.13042","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T08:18:29Z","timestamp":1706257109000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal neighbourhood\u2010level social determinants of health and their association with paediatric hepatitis C screening among children exposed to hepatitis C in pregnancy"],"prefix":"10.1111","volume":"38","author":[{"given":"Mary K.","family":"Foley","sequence":"first","affiliation":[{"name":"Department of Medicine Queen's University  Kingston Ontario Canada"},{"name":"Department of Public Health Sciences Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Djerboua","sequence":"additional","affiliation":[{"name":"ICES Queens  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Kushner","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine  New York New York USA"},{"name":"Department of Obstetrics Gynecology and Reproductive Sciences, Icahn School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia J.","family":"Biondi","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease, Toronto General Hospital University Health Network, University of Toronto  Toronto Ontario Canada"},{"name":"School of Nursing, Faculty of Health Sciences York University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan J.","family":"Feld","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease, Sandra Rotman Centre for Global Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah A.","family":"Terrault","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases Keck School of Medicine at University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-0925","authenticated-orcid":false,"given":"Jennifer A.","family":"Flemming","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen's University  Kingston Ontario Canada"},{"name":"Department of Public Health Sciences Queen's University  Kingston Ontario Canada"},{"name":"ICES Queens  Kingston Ontario Canada"},{"name":"Division of Cancer Care and Epidemiology Queen's Cancer Research Institute  Kingston 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