{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:11:56Z","timestamp":1788952316925,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["20\u2010B\u20100388"],"award-info":[{"award-number":["20\u2010B\u20100388"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Development of the gonads during fetal life is complex and vital for adult reproductive health. Cell and animal studies have shown an alarming effect of mild analgesics on germ cells in both males and females. More than 50% of pregnant women use mild analgesics during pregnancy, which potentially could compromise the reproductive health of the next generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We present a research protocol designed to evaluate the effect of prenatal exposure to mild analgesics and endocrine\u2010disrupting chemicals on gonadal function in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Healthy, singleton pregnant women and their partners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The COPANA cohort is a prospective, observational pregnancy and birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were enrolled during the first trimester of pregnancy. Information on the use of mild analgesics was collected retrospectively 3\u2009months prior to pregnancy and prospectively every 2\u2009weeks throughout the study. We collected extensive data on lifestyle and reproductive health. Biospecimens were collected in the first trimester (maternal and paternal urine\u2010 and blood samples), in the third trimester in conjunction with a study\u2010specific ultrasound scan (maternal urine sample), and approximately 3\u2009months post\u2010partum during the infant minipuberty period (maternal and infant urine\u2010 and blood samples). A comprehensive evaluation of reproductive function in the infants during the minipuberty phase was performed, including an ultrasound scan of the testis or ovaries and uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Preliminary Results<\/jats:title><jats:p>In total, 685 pregnant women and their partners were included between March 2020 and January 2022. A total of 589 infants (287 males) and their parents completed the follow\u2010up during the minipuberty phase (December 2020\u2014November 2022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Copenhagen Analgesic Study holds the potential to provide novel and comprehensive insights into the impact of early and late prenatal exposure to mild analgesics and other endocrine\u2010disrupting chemicals on future reproductive function in the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.13058","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T01:44:25Z","timestamp":1709862265000},"page":"370-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cohort profile: The Copenhagen Analgesic Study\u2014The <scp>COPANA<\/scp> 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