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First, we determined if women who enrolled at the Utah site (<jats:italic>N<\/jats:italic>\u2009=\u20091001) of the EAGeR trial (2007\u20132011, <jats:italic>N<\/jats:italic>\u2009=\u20091228) could successfully be contacted and agree to complete an online questionnaire on their reproductive, cardio\u2010metabolic, and offspring respiratory health 9\u201314\u2009years after original enrollment. Second, we evaluated if maternal exposure to low\u2010dose aspirin (LDA) during pregnancy was associated with maternal cardio\u2010metabolic health and offspring respiratory health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The original EAGeR study population included women, 18\u201340\u2009years of age, who had 1\u20132 prior pregnancy losses, and who were trying to become pregnant. At follow\u2010up (2020\u20132021), participants from the Utah cohort completed a 13\u2010item online questionnaire on reproductive and cardio\u2010metabolic health, and those who had a live birth during EAGeR additionally completed a 7\u2010item questionnaire on the index child's respiratory health. Primary maternal outcomes included hypertension and hypercholesterolemia; primary offspring outcomes included wheezing and asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight percent (<jats:italic>n<\/jats:italic>\u2009=\u2009678) of participants enrolled in the follow\u2010up study, with 10% and 15% reporting maternal hypertension and hypercholesterolemia, respectively; and 18% and 10% reporting offspring wheezing and asthma. We found no association between maternal LDA exposure and hypertension (risk difference [RD] \u22120.001, 95% confidence interval [CI] \u22120.05, 0.04) or hypercholesterolemia (RD \u22120.01, 95% CI \u22120.06, 0.05) at 9\u201314\u2009years follow\u2010up. Maternal LDA exposure was not associated with offspring wheezing (RD \u22120.002, 95% CI \u22120.08, 0.08) or asthma (RD 0.13, 95% CI 0.11, 0.37) at follow\u2010up. Findings remained robust after considering potential confounding and selection bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed no association between LDA exposure during pregnancy and maternal cardiometabolic or offspring respiratory health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.13097","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T03:00:12Z","timestamp":1718679612000},"page":"570-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low\u2010dose aspirin, maternal cardiometabolic health, and offspring respiratory health 9 to 14\u2009years after delivery: Findings from the <scp>EAGeR<\/scp> Follow\u2010up Study"],"prefix":"10.1111","volume":"38","author":[{"given":"May","family":"Shaaban","sequence":"first","affiliation":[{"name":"Department of Family and Preventive Medicine University of Utah Health  Salt\u00a0Lake City Utah 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