{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:33:08Z","timestamp":1769232788964,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0054286"],"award-info":[{"award-number":["NNF19OC0054286"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004331","name":"Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond","doi-asserted-by":"publisher","award":["J 167\/1"],"award-info":[{"award-number":["J 167\/1"]}],"id":[{"id":"10.13039\/501100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020035","name":"A. P. M\u00f8llerske St\u00f8ttefond","doi-asserted-by":"publisher","award":["L\u20102022\u201000290"],"award-info":[{"award-number":["L\u20102022\u201000290"]}],"id":[{"id":"10.13039\/100020035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003491","name":"Herlev Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maternal preeclampsia is associated with both congenital heart defects and changes in left ventricular structure and function in the offspring. Whether preeclampsia and gestational hypertension also affect the offspring's cardiac conduction system is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study assesses whether infants exposed to maternal hypertensive disorders of pregnancy (HDPs) exhibit changes in their electrocardiogram (ECG) compared with infants unexposed to HDPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This population\u2010based cohort study included newborns from the Copenhagen Baby Heart Study who had an ECG performed within 30\u2009days of birth and had available obstetric information. ECG parameters of newborns exposed to maternal HDPs were compared with those of unexposed newborns using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study cohort included 11,826 newborns, including 441 exposed to maternal preeclampsia and 320 exposed to gestational hypertension. Infants exposed to preeclampsia had prolonged QRS durations (adjusted mean difference 0.6\u2009ms, 95% confidence interval [CI] 0.04, 1.16) and lower maximum amplitudes of the R\u2010wave in V1 (adjusted mean difference, linear scale 0.95, 95% CI 0.90, 1.00), compared with unexposed infants. Exposure to maternal preeclampsia was not associated with changes in other ECG parameters. Exposure to gestational hypertension was associated with increased QT interval durations (QT<jats:sub>c<\/jats:sub> Bazett, adjusted mean difference 2.48\u2009ms, 95% CI \u22120.23, 5.20; QT<jats:sub>c<\/jats:sub> Fridericia, adjusted mean difference 2.32\u2009ms, 95% CI \u22120.19, 4.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the newborn cardiac conduction system is affected by exposure to maternal preeclampsia. This could reflect the previously described thickening of the left ventricular myocardium in infants exposed to preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.13117","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T08:24:36Z","timestamp":1728030276000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal hypertensive disorders of pregnancy and electrocardiographic findings among newborns: The Copenhagen Baby Heart Study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9995-2762","authenticated-orcid":false,"given":"Emil H.","family":"N\u00f8rskov","sequence":"first","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-6077","authenticated-orcid":false,"given":"Maria M.","family":"P\u00e6rregaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-3309","authenticated-orcid":false,"given":"Anna A.","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Heart Centre, Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-1016","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Sillesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-1496","authenticated-orcid":false,"given":"Alex H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Cardiology The Heart Centre, Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Heart Centre, Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-9985","authenticated-orcid":false,"given":"Heather A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-8487","authenticated-orcid":false,"given":"Kasper K.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Cardiology The Heart Centre, Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6982-5105","authenticated-orcid":false,"given":"R. 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