{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:04:19Z","timestamp":1790651059762,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Population\u2010based data are needed to reliably assess the impact of SARS\u2010CoV\u20102 infection during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the population\u2010based incidence of SARS\u2010CoV\u20102 infection and its severe forms in the obstetric population, identify risk factors of severe SARS\u2010CoV\u20102 infection (severe COVID\u201019) and describe delivery, maternal and neonatal outcomes by disease severity, using a definition of severity based on organ dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective population\u2010based study conducted over the three first pandemic waves between March 2020 and April 2021 in 281 maternity hospitals in six French regions included all women with SARS\u2010CoV\u20102 infection during pregnancy or within 7\u2009days post\u2010partum, whether symptomatic or not, hospitalised or not. Severe COVID\u201019 forms were defined a priori using clinical, biological and management criteria of organ dysfunction. We calculated infection and severe infection rates and studied associations between sociodemographic, medical and pregnancy characteristics and severe COVID\u201019 by univariate and multivariate modified Poisson regression modelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a population of 385,214 deliveries in the participating regions, 6015 women with SARS\u2010CoV\u20102 infection were identified, including 337 severe cases. The rates of severe COVID\u201019 were 1.1, 0.9 and 3.6 per 1000 deliveries during the first, second and third pandemic waves, respectively, and the proportions of severe COVID\u201019 were 8.6%, 3.4% and 9.3%, respectively. On multivariate analysis, the risk of severe COVID\u201019 was associated with younger and older age, migrant status, living with &gt;\u20094 people, overweight or obesity, chronic hypertension or diabetes and infection \u2265\u200922\u2009weeks of gestation rather than earlier in pregnancy. Neonatal morbidity occurred mostly with severe maternal infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using an organ\u2010based definition of severity and population\u2010based data, rates of severe COVID\u201019 appeared lower than in previous studies. A permanent perinatal surveillance system is needed to assess efficiently and rapidly the impact of future pandemics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.70028","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:43:55Z","timestamp":1747802635000},"page":"477-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence, Risk Factors and Outcomes of SARS\u2010CoV\u20102 Infection in Pregnant Women: The COROPREG Population\u2010Based Study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-0991","authenticated-orcid":false,"given":"Caroline","family":"Diguisto","sequence":"first","affiliation":[{"name":"Obstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epid\u00e9miologie et StatistiqueS (CRESS), INSERM, INRAE Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord  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AURORE, H\u00f4pital de la Croix Rousse, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Garabedian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, ULR 2694\u2010METRICS CHU Lille, University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lebeaux","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Centre Hospitalier Intercommunal de Cr\u00e9teil  Cr\u00e9teil France"},{"name":"R\u00e9seau Perinatal du Val de Marne  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-1063","authenticated-orcid":false,"given":"Camille","family":"Le Ray","sequence":"additional","affiliation":[{"name":"Obstetrical, Perinatal and Pediatric Life Course Epidemiology (OPPALE Team), Centre de Recherche Epid\u00e9miologie et StatistiqueS (CRESS), INSERM, 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