{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:06:55Z","timestamp":1791994015480,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000101"],"award-info":[{"award-number":["2016YFC1000101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202408110195"],"award-info":[{"award-number":["202408110195"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal anaemia is a public health issue globally, associated with adverse maternal and neonatal outcomes. However, less is known about the effects of high haemoglobin (Hb) and haematocrit (Hct) on the risk of stillbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the dose\u2013response effects of dynamic changes in maternal Hb and Hct across all trimesters on stillbirth risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was based on the prospective, longitudinal, population\u2010based China birth cohort study (CBCS) between 2018 and 2022, including 142,715 women with live births or stillbirths delivered at \u2265\u200920\u2009weeks' gestation. The modified Poisson regression models were used to assess the association between Hb\/Hct, haemodilution status across three trimesters and stillbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a fifth (23.6%) of pregnant women had anaemia at least once during pregnancy. Maternal anaemia increased the risk of stillbirth. The adjusted risk ratio (aRR) for Hb at 70\u201399\u2009g\/L (moderate anaemia) was 2.45, 95% confidence interval (CI) 1.26, 4.76 and aRR for Hct &lt;\u200933% (anaemia) was 1.63 (95% CI 1.12, 2.38) in the first trimester. Interestingly, a U\u2010shaped association between Hb\/Hct and stillbirth was observed, and high Hb\/Hct levels in any of the three trimesters were related to increased stillbirth risk. Excessive haemoglobin dilution\/haemoglobin concentration across trimesters was also associated with higher stillbirth risk, especially from the first to the second trimesters, with aRRs of 1.86 (95% CI 1.15, 3.01) and 3.34 (95% CI 2.08, 5.37), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Considering the U\u2010shaped association between Hb\/Hct levels and stillbirth, clinical vigilance is necessary at both low\u2010 and high\u2010extremes of Hb\/Hct and physiological haemodilution metrics in mid\u2010to\u2010late pregnancy for improved pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.70144","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:30:55Z","timestamp":1775021455000},"page":"709-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal Haemoglobin and Haematocrit During Pregnancy and Stillbirth Risk: A Prospective, Population\u2010Based Birth Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-8071","authenticated-orcid":false,"given":"Shuangying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Engineering Manchester Metropolitan University  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1205-7487","authenticated-orcid":false,"given":"Minhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-1125","authenticated-orcid":false,"given":"Wentao","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital  Beijing China"},{"name":"Department of Research Management Beijing Obstetrics and Gynecology Hospital, Capital Medical University. 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