{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:01:52Z","timestamp":1790751712492,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal hypertension has been linked to adverse pregnancy and neonatal outcomes, but long\u2010term effects on offspring, particularly gastrointestinal (GI) health, are less well studied. Chronic hypertension may impair uteroplacental perfusion and promote a pro\u2010inflammatory intrauterine environment, potentially disrupting foetal gut development; however, its independent effect on offspring GI health has not been examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether in utero exposure to maternal chronic hypertension, independent of preeclampsia, is associated with long\u2010term GI morbidity in offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population\u2010based retrospective cohort study included all singleton deliveries at a tertiary medical centre over a 30\u2010year period (1991\u20132021). Offspring were followed until age 18 for GI diagnoses based on ICD\u20109 codes from hospital and outpatient records. The primary exposure was maternal chronic hypertension, and the primary outcome was the incidence of GI morbidity in offspring. Piecewise Poisson log\u2010linear models estimated adjusted incidence rate ratios (IRR), controlling for maternal age, parity, ethnic origin, smoking, obesity, and pre\u2010gestational diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 342,635 singleton deliveries, 3097 (0.9%) were to mothers with chronic hypertension. The median follow\u2010up was 12.6\u2009years (interquartile range 5.6, 18.0). GI incidence rates were 1903.0 and 1901.9 per 100,000 person\u2010years among chronic hypertension and normotensive groups. Offspring of mothers with chronic hypertension showed lower GI risk in early childhood (adjusted IRR &lt;\u20091\u2009year: 0.34, 95% confidence interval [CI] 0.11, 1.05; 1\u20133\u2009years: 0.46, 95% CI 0.29, 0.73), with estimates consistent with no difference in late adolescence (15\u201318\u2009years: adjusted IRR 1.09, 95% CI 0.98, 1.21). All\u2010cause mortality was low and similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association between maternal chronic hypertension and offspring GI morbidity is time\u2010varying and non\u2010proportional, with lower risk in early childhood and no evidence of excess risk at later ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.70148","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:24:48Z","timestamp":1776317088000},"page":"824-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Gastrointestinal Outcomes in Children Exposed in Utero to Maternal Chronic Hypertension"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6710-2746","authenticated-orcid":false,"given":"Nir","family":"Roguin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Soroka University Medical Centre, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Gutvirtz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Soroka University Medical Centre, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gali","family":"Pariente","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Soroka University Medical Centre, Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 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