{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:21:52Z","timestamp":1787894512944,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infant mortality has recently increased in France, especially in deprived areas. Congenital anomalies (CA) are a major cause of infant mortality and could contribute to these trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate socio\u2010spatial inequalities in infant mortality associated with CA. It also examined socio\u2010spatial differences in antenatal detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included all live births \u2265\u200922\u2009weeks with CA from the Paris Registry of CA (remaPAR). Births are linked to infant deaths &lt;\u20091\u2009year using vital statistics records. A case\u2010population design was applied to assess the association between an area\u2010based deprivation score, assigned at the smallest census tract level (IRIS) of the mother's place of residence, and risks of infant death and live birth with CA. In the absence of data on births at the IRIS level, we used an aggregated population comparison group of children &lt;\u20092\u2009years old in 2019\u20132022 census data. We computed unadjusted odds ratios (OR) by comparing the distribution of the area\u2010based score in quartiles in the case and census comparison populations. We also compared antenatal detection of CA by deprivation quartile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 2539 live births, resulting in 81 infant deaths. The proportions of infant deaths with CA were 39.5% and 16.0% in the most and least deprived quartiles, respectively, yielding an OR of 2.43 (95% confidence interval [CI] 1.28, 4.63). For live births with CA, these percentages were 29.7% and 22.0% with an OR of 1.34 (95% CI 1.20, 1.49). No variation across quartiles was observed in antenatal detection of CA, with a detection rate of 56.0% for live births and 85.2% for infant deaths. First\u2010trimester ultrasound use was high (90.5%) but was lower in the most compared to the least deprived quartile (87.8% and 93.9%, respectively); however, second\u2010trimester ultrasound use was similar across quartiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Area\u2010based deprivation was associated with higher risks of infant mortality and live birth with CA, but not antenatal detection of CA. These results raise questions about differences in CA aetiology and decision\u2010making about termination of pregnancy after CA detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.70162","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:45:16Z","timestamp":1780299916000},"page":"694-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Social Inequalities in Infant Mortality Related to Congenital Anomalies: A Population\u2010Based Register Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8328-0372","authenticated-orcid":false,"given":"Bermet","family":"Amirova","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lelong","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Victoire","family":"S\u00e9nat","sequence":"additional","affiliation":[{"name":"Clinique Des Femmes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-4915","authenticated-orcid":false,"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Monier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and Statistics  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029424"},{"key":"e_1_2_11_3_1","unstructured":"Insee \u201cMortality Demographic Balance Sheet 2023\u2014Retrospective Tables \u201d(2025) https:\/\/www.insee.fr\/en\/statistiques\/7748152."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeph.2024.202805"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2024-000954"},{"key":"e_1_2_11_6_1","unstructured":"WHO \u201cCongenital Disorders \u201d(2025) https:\/\/www.who.int\/health\u2010topics\/congenital\u2010anomalies."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1892"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2024.102780"},{"key":"e_1_2_11_9_1","first-page":"225","article-title":"Association Between Congenital Anomalies and Area\u2010Level Deprivation Among Infants in Neonatal Intensive Care Units","volume":"30","author":"Bassil K. 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