{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:01Z","timestamp":1787991361078,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201023\u2010CE36\u20100003\u20100"],"award-info":[{"award-number":["ANR\u201023\u2010CE36\u20100003\u20100"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pregnancy represents a crucial period for understanding key pathways contributing to the intergenerational effects of adverse childhood experiences (ACEs). However, prenatal mechanisms linking maternal ACEs to subsequent child mental health outcomes are still poorly understood compared to postnatal ones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the biopsychosocial mechanisms during pregnancy that may contribute to the relationship between maternal ACEs and child socio\u2010emotional and behavioural development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We systematically searched PubMed, PsycInfo and Web of Science from inception up to February 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection and Data Extraction<\/jats:title>\n                    <jats:p>We included peer\u2010reviewed observational studies (cohort, case\u2013control, cross\u2010sectional) evaluating prenatal biological, psychological, or social mechanisms linking maternal ACEs to child socio\u2010emotional\/behavioural outcomes (Ages 0\u201318); qualitative studies and grey literature were excluded. Two reviewers independently screened studies and extracted data on study design, mediators and effect sizes, with disagreements resolved by a third reviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Synthesis<\/jats:title>\n                    <jats:p>Narrative synthesis was used to summarise study characteristics, mediation pathways and analytical strategies in tabular form. Results were synthesised by type of prenatal mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2641 records identified, 122 full texts were assessed and 13 studies met inclusion criteria. Prenatal maternal depression and anxiety emerged as the most frequently studied mechanisms, showing some evidence of independent effects irrespective of postnatal factors, but most of the findings point towards a \u2018chain\u2010of\u2010risk\u2019 model, where prenatal mental health interacts with the postnatal environment. Biomedical antepartum risks and maternal\u2013fetal attachment also showed mediating effects, but without accounting for postnatal influences. The small number of eligible studies underscores the limited exploration of prenatal transmission pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prenatal mental health difficulties, particularly in interaction with postnatal factors, may play a role in the intergenerational transmission of ACEs. Further studies using robust methods to disentangle prenatal and postnatal contributions are needed to inform targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.70190","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:21:11Z","timestamp":1787988071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Adverse Childhood Experiences and Child Socio\u2010Emotional and Behavioural Outcomes: A Systematic Review of Prenatal Mechanisms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-837X","authenticated-orcid":false,"given":"Sara","family":"Avendano","sequence":"first","affiliation":[{"name":"Social Epidemiology, Mental Health, and Addiction Team (ESSMA), Sorbonne Public Health Institute, INSERM Sorbonne University  Paris 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