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Despite their simple structure, viroids like Potato Spindle Tuber Viroid (PSTVd) can interfere with plant cellular processes, including transcriptional and post\u2010transcriptional mechanisms, impacting plant growth and yield. In this study, we have investigated the role of the Target Of Rapamycin (TOR) signaling pathway in modulating viroid pathogenesis in tomato plants infected with PSTVd. Our findings reveal that PSTVd infection induces the accumulation of the selective autophagy receptor NBR1, potentially inhibiting autophagic flux. Pharmacological inhibition of TOR with AZD8055 mitigated PSTVd symptomatology by reducing viroid accumulation. Furthermore, TOR inhibition promoted the recovery of autophagic flux through NBR1. It primed the plant defense response, as evidenced by enhanced expression of the defense\u2010related gene\n                    <jats:italic>PR1b<\/jats:italic>\n                    and\n                    <jats:italic>S5H<\/jats:italic>\n                    , a gene involved in the salicylic acid catabolism. These results suggest a novel role for TOR in regulating viroid\u2010induced pathogenesis and highlight the potential of TOR inhibitors as tools for enhancing plant resistance against viroid infections.\n                  <\/jats:p>","DOI":"10.1111\/ppl.14606","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T03:09:46Z","timestamp":1731640186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>TOR<\/scp>\n                    Inhibition Enhances Autophagic Flux and Immune Response in Tomato Plants Against\n                    <scp>PSTVd<\/scp>\n                    Infection"],"prefix":"10.1111","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6652-4336","authenticated-orcid":false,"given":"Samanta","family":"Silva\u2010Valencia","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP) CSIC\u2010Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"},{"name":"Present address: Instituto de Biolog\u00eda Integrativa de Sistemas (I<sup>2<\/sup>SysBio) CSIC\u2010Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-6571","authenticated-orcid":false,"given":"Francisco V\u00e1zquez","family":"Prol","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP) CSIC\u2010Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-6112","authenticated-orcid":false,"given":"Ismael","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP) CSIC\u2010Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-8084","authenticated-orcid":false,"given":"Purificaci\u00f3n","family":"Lis\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP) CSIC\u2010Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-1917","authenticated-orcid":false,"given":"Borja","family":"Belda\u2010Palaz\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP) CSIC\u2010Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV-PHYTO-080508-081927\/CITE\/REFWORKS"},{"key":"e_1_2_10_3_1","first-page":"47","article-title":"Photosynthesis, a global sensor of environmental stress in green plants: stress signalling and adaptation","volume":"101","author":"Biswal B.","year":"2011","journal-title":"Curr Sci"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENVEXPBOT.2023.105426"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1751\/655399\/P\/AZD8055-IS-A-POTENT-SELECTIVE-AND-ORALLY"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/JXB\/ERAC361"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKZ679"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/NPH.14785"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/JGV.0.001045\/CITE\/REFWORKS"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/JGV.0.001543\/CITE\/REFWORKS"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PBI.2005.09.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FEBSLET.2004.03.118"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV\u2010MICRO\u2010091313\u2010103416\/CITE\/REFWORKS"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796697"},{"key":"e_1_2_10_15_1","first-page":"181","article-title":"Emergencia del viroide del tub\u00e9rculo ahusado de la papa (Potato spindle tuber viroid) (PSTVd) en la regi\u00f3n del Caribe","volume":"18","author":"Gonz\u00e1lez Arias G.","year":"2014","journal-title":"Fitosanidad"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/V11110992"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1610687114\/SUPPL_FILE\/PNAS.201610687SI.PDF"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1104\/PP.17.01198"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"Hammond R.W. 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