{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:41:45Z","timestamp":1785325305660,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072403 31871945"],"award-info":[{"award-number":["32072403 31871945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiologia Plantarum"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Small signalling molecules, such as salicylic acid (SA) and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxypipecolic acid (NHP), act synergistically to activate systemic acquired resistance (SAR), a major form of plant inducible immunity. The transcriptional regulation of SA biosynthesis controlled by different transcription factors (TFs) has been well documented in SAR. Several TFs, e.g., SARD1, CBP60g and WRKY33, positively regulate NHP biosynthesis; however, direct negative modulators have remained elusive. Recently, Cai et al. (2024) identified a NAC triad composed of NAC\u2010type TFs, NAC90, NAC36, and NAC61, that negatively regulates NHP and SA biosynthesis. NAC90 and NAC36 act as negative regulators of plant immunity by repressing transcription of\n                    <jats:italic>ALD1<\/jats:italic>\n                    ,\n                    <jats:italic>FMO1<\/jats:italic>\n                    , and\n                    <jats:italic>ICS1<\/jats:italic>\n                    , the major NHP and SA biosynthetic genes, via direct binding to their promoters. These TFs, along with another NAC TF, NAC61, form heterodimers, further enhancing their repressive effects on NHP and SA biosynthesis. These findings establish the NAC90\u2010NAC61\u2010NAC36 triad as a negative regulator of NHP and SA levels. In this viewpoint article, we present our perspectives on further investigations to gain comprehensive insight into transcriptional regulation of SAR signal homeostasis.\n                  <\/jats:p>","DOI":"10.1111\/ppl.70123","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T22:20:18Z","timestamp":1739744418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>NAC<\/scp>\n                    transcription factors transcriptionally fine\u2010tune signal homeostasis in plant systemic acquired resistance"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4662-1201","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"National Key Laboratory for Rice Biology and Breeding Institute of Biotechnology, Zhejiang University  Hangzhou China"},{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of Biotechnology, Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of Biotechnology, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1326-7019","authenticated-orcid":false,"given":"Leeza","family":"Tariq","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Rice Biology and Breeding Institute of Biotechnology, Zhejiang University  Hangzhou China"},{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of Biotechnology, Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of Biotechnology, Zhejiang University  Hangzhou 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