{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:13:17Z","timestamp":1784221997770,"version":"3.55.0"},"reference-count":87,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiologia Plantarum"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Both hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) and gamma\u2010aminobutyric acid (GABA) are known to regulate antioxidative metabolic pathways for developing stress resilience in plants. However, it is unknown whether they work together or exhibit independent signaling in maintaining ROS homeostasis during cadmium (Cd) stress. Therefore, this study was undertaken to investigate the potential implications of GABA and H\n                    <jats:sub>2<\/jats:sub>\n                    S signaling in regulating Cd stress in rice seedlings. The results show that the exposure to Cd stress affects photosynthesis and nitrogen assimilation, increases ROS accumulation, weakens the antioxidant system, and disturbs thiol metabolism in rice seedlings. Cd stress also stimulated aerenchyma formation, which was further enhanced by GABA application, while H\n                    <jats:sub>2<\/jats:sub>\n                    S did not exhibit any significant effect. GABA treatment also decreased the Cd\u2010induced tannin deposition in roots. Moreover, exogenous GABA and H\n                    <jats:sub>2<\/jats:sub>\n                    S application also enhanced plant growth and chlorophyll content, and restored photosynthesis and nitrogen homeostasis by stabilizing NR, NiR, and GS\/GOGAT activities under Cd stress. Further, thiol metabolism was also strengthened, aiding in redox balance restoration under Cd stress. GABA was more effective than H\n                    <jats:sub>2<\/jats:sub>\n                    S in mitigating Cd stress. Moreover, both GABA and H\n                    <jats:sub>2<\/jats:sub>\n                    S were capable of mitigating Cd stress, and our results revealed that GABA seems to be a downstream component of H\n                    <jats:sub>2<\/jats:sub>\n                    S signaling. The results of this study highlight a hopeful and sustainable approach for refining crop resilience to heavy metal stress and Cd stress in particular.\n                  <\/jats:p>","DOI":"10.1111\/ppl.70490","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:40:41Z","timestamp":1757907641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Interplay Between Gama\u2010Aminobutyric Acid and Hydrogen Sulfide and Their Potential Role in Mitigating Cadmium Toxicity in Rice Seedlings"],"prefix":"10.1111","volume":"177","author":[{"given":"Saumya","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Plant Physiology Laboratory, Department of Botany C.M.P. Degree College, A Constituent Post Graduate College of University of Allahabad  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiksha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Botany S.N. Sen B.V. Post Graduate College, Chhatrapati Shahu Ji Maharaj University  Kanpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-9528","authenticated-orcid":false,"given":"Ravi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Plant Stress Physiology and Proteomics Laboratory, College of General Education Kookmin University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9044-3144","authenticated-orcid":false,"given":"Durgesh Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Crop Nanobiology and Molecular Stress Physiology Lab, Amity Institute of Organic Agriculture Amity University Uttar Pradesh  Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-5438","authenticated-orcid":false,"given":"Vijay Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Plant Physiology Laboratory, Department of Botany C.M.P. Degree College, A Constituent Post Graduate College of University of Allahabad  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2020.07.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.13168"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rsci.2021.03.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.933694"},{"key":"e_1_2_8_6_1","volume-title":"Determination of Water Deficits in Plant Tissues","author":"Barrs H.","year":"1968"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90206-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21580103.2015.1044024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.776971"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erz031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.103.018648"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2024.103961"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-018-1994-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2005.09.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.postharvbio.2010.03.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09094"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11738-012-1167-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10643389.2020.1835435"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.14116"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1040627"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.130435"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12982"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111887"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10535-012-0286-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(75)90682-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20240215"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1232"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.00800"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.91.4.1527"},{"key":"e_1_2_8_30_1","first-page":"4731","article-title":"A Novel Spectrophotometric Method for the Trace Analysis of Glucose","volume":"4","author":"Hussain Z.","year":"2011","journal-title":"Journal of Pharmacy Research"},{"key":"e_1_2_8_31_1","first-page":"1074","article-title":"Effects of Cadmium Toxicity in Plants: A Review Article","volume":"4","author":"Jali P.","year":"2016","journal-title":"Scholarly Academic Journal of Bioscience"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-024-05309-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12947"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/01904160600837238"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12061"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apgeochem.2019.104388"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11738-006-0030-1"},{"issue":"4","key":"e_1_2_8_38_1","first-page":"751","article-title":"Effects of cd 2+ Ions on Root Anatomical Structure of Four Rice Genotypes","volume":"35","author":"Li B.","year":"2014","journal-title":"Journal of Environmental Biology"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243835"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592324.2020.1862565"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-019-04051-8"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/15226514.2013.828020"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.118867"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)48036-1"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1984.tb05899.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113683"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-020-04471-x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.02.026"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.13546"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592324.2022.2163343"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2024.109001"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00344-022-10778-z"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14078"},{"key":"e_1_2_8_54_1","first-page":"25","article-title":"Leaf Relative Water Content","volume":"25","author":"Mullan D.","year":"2012","journal-title":"Physiological Breeding II: A Field Guide to Wheat Phenotyping"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/23311932.2019.1670553"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-020-00522-0"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11738-016-2277-5"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.144164"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86401-0"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3426-9_15"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eraa289"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-021-02711-7"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)00825-7"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42703-7"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59592-1"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137049"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00344-019-10018-x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-020-00696-y"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.01948"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1983.tb02784.x"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.1986.tb05944.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.13065"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40502-020-00553-1"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2021.04.004"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.2306\/scienceasia1513-1874.2004.30.411"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042110-103921"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.00452"},{"issue":"8","key":"e_1_2_8_78_1","first-page":"1455","article-title":"The Activation State of Ribulose 1, 5\u2010Bisphosphate Carboxylase in Maize Leaves in Dark and Light","volume":"26","author":"Usuda H.","year":"1985","journal-title":"Plant and Cell Physiology"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054816"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125674"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.177403"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2015.10.001"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0570508"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1685-2"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146358"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.119661"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01079"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00344-016-9599-9"}],"container-title":["Physiologia Plantarum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppl.70490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ppl.70490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppl.70490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:23:43Z","timestamp":1776248623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppl.70490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ppl.70490"],"URL":"https:\/\/doi.org\/10.1111\/ppl.70490","archive":["Portico"],"relation":{},"ISSN":["0031-9317","1399-3054"],"issn-type":[{"value":"0031-9317","type":"print"},{"value":"1399-3054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70490"}}