{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:49:56Z","timestamp":1782294596448,"version":"3.54.5"},"reference-count":80,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiologia Plantarum"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plants produce a wide array of bioactive compounds that are essential for both plants and humans. Among those compounds, tocopherols (vitamin E) are lipid\u2010soluble antioxidants that play key roles in plant protection and human health. Precursors of tocopherols are homogentisic acid (HGA) and phytyl diphosphate (PDP). It has long been established that PDP is primarily synthesized de novo via the plastidial 2\u2010C\u2010methyl\u2010D\u2010erythritol 4\u2010phosphate (MEP) pathway. However, studies in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    <\/jats:styled-content>\n                    , maize, and tomato showed that phytol, a byproduct of chlorophyll degradation, can be synthesized into PDP and utilized for tocopherol production. The studies have demonstrated metabolic and genetic links between chlorophyll metabolism and tocopherol synthesis through phytol recycling, as evidenced by transgenic lines, genome\u2010wide association studies, and light\u2010intensity treatments. While previous reviews have focused mainly on the core tocopherol biosynthesis pathway and its regulation, this integration of chlorophyll degradation\u2010derived phytol recycling with genetic and environmental regulation is rarely discussed. Therefore, the recent information prompted us to conduct a comprehensive literature review that integrates metabolic, genetic, and environmental factors underlying the relationship between chlorophyll metabolism and tocopherol synthesis in plants. This review aims to gather current knowledge on this relationship, highlight its biological and environmental significance, and discuss potential applications for biofortification.\n                  <\/jats:p>","DOI":"10.1111\/ppl.70963","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:01:02Z","timestamp":1781676062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulatory Crosstalk Between Tocopherol Biosynthesis and Chlorophyll Metabolism in Plants: Current Insights"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-807X","authenticated-orcid":false,"given":"Deshika","family":"Panapitiya","sequence":"first","affiliation":[{"name":"Laboratory of Applied Plant Genomics, Graduate School of Agriculture Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-0612","authenticated-orcid":false,"given":"Maria Stefanie","family":"Dwiyanti","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Plant Genomics, Research Faculty of Agriculture Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2008.01907.x"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113488119"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01396"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erv504"},{"issue":"6","key":"e_1_2_15_6_1","first-page":"593","article-title":"Antioxidants and Accumulation of \u03b1\u2010Tocopherol Induce Chilling Tolerance in \n                     Medicago sativa","volume":"10","author":"Bafeel S. O.","year":"2008","journal-title":"International Journal of Agriculture and Biology"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koaf021"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13007-020-00671-9"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<913::AID-JSFA600>3.0.CO;2-3"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt853"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochms.2023.100170"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.013656"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100598"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.026138"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00475"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.15.00395"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100363a001"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.5772\/1008"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100854200"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12298-023-01354-0"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox6040099"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.1992.tb00988.x"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.4025\/actasciagron.v34i3.12660"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4133(199910)101:10<400::AID-LIPI400>3.0.CO;2-#"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.13467"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100530"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11032-020-01184-y"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.037036"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-025-06267-6"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.043927"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2016.05.004"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2015.00013"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2005.05.005"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510413.x"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11091258"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2019.10.005"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10919"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2010.08.003"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-019-2028-z"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129915"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2489-2"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-020-02424-1"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.15.00860"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.039404"},{"issue":"4","key":"e_1_2_15_45_1","first-page":"376","article-title":"So Many Options but One Choice: The Human Body Prefers \u03b1\u2010Tocopherol. A Matter of Stereochemistry","volume":"1","author":"Manolescu B.","year":"2008","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7010002"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803611105"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20230399"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-011-4138-1"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.17.01384"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1344095"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.743993"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.032441"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.89.4.1028"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koad316"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04784.x"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.021360"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031093"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200400049"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-013-1356-6"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf100455f"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.5.3.10739"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/217037"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.3.949"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)80189-X"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erx356"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811684106"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcae093"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.120.3.695"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004699107"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.037077"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.015875"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12889"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122480"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2021.153579"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcaa115"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12067"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.15.00594"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.850924"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2025.1613360"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075299"}],"container-title":["Physiologia Plantarum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppl.70963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ppl.70963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppl.70963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:39:31Z","timestamp":1782293971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppl.70963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ppl.70963"],"URL":"https:\/\/doi.org\/10.1111\/ppl.70963","archive":["Portico"],"relation":{},"ISSN":["0031-9317","1399-3054"],"issn-type":[{"value":"0031-9317","type":"print"},{"value":"1399-3054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70963"}}