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Conventional approaches based on single\u2010stress responses are increasingly insufficient for addressing complex field environments where plants experience multiple simultaneous stresses. This review synthesizes current knowledge on plant physiological responses, microbiome interactions, and emerging technological interventions to develop an integrative framework for climate\u2010resilient agriculture. It highlights how stress perception, hormonal regulation, metabolic adjustments, and epigenetic mechanisms collectively shape plant adaptation under multi\u2010stress conditions. The review further examines the role of plant\u2010associated microbiomes in enhancing nutrient acquisition, regulating stress signaling, and improving resilience through mechanisms such as phytohormone modulation, antioxidant activity, and induced systemic resistance. 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