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Stripe rust, caused by\n                    <jats:italic>Puccinia striiformis<\/jats:italic>\n                    f. sp.\n                    <jats:italic>tritici<\/jats:italic>\n                    (\n                    <jats:italic>Pst<\/jats:italic>\n                    ), is a major constraint on global wheat production. The\n                    <jats:italic>Yr15<\/jats:italic>\n                    resistance gene, derived from wild emmer wheat, encodes the tandem kinase protein WTK1. To define the temporal basis of this resistance, we analysed resistant and susceptible near\u2010isogenic lines across a 7\u2010day infection time course using histopathology, ROS phenotyping, RNA sequencing, co\u2010expression network analysis, and qRT\u2010PCR validation. WTK1\u2010mediated resistance limited fungal colonization, enhanced ROS accumulation, and triggered extensive transcriptional reprogramming. We identified 2509 pathogen\u2010responsive differentially expressed genes, including 1530 genes upregulated in the resistant line, revealing an early phase enriched for ROS and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling, autophagy\u2010related processes, and metacaspases consistent with hypersensitive cell death observed in pathogen\u2010invaded cells. This was followed by later defense reinforcement and metabolic reprogramming in later stages of infection, including pathogenesis\u2010related proteins, cell\u2010wall reinforcement, and phytoalexin biosynthesis, consistent with the confinement of\n                    <jats:italic>Pst<\/jats:italic>\n                    to localized necrotic lesions. Our results show that WTK1 triggers coordinated waves of transcriptional reprogramming and co\u2010expression network responses during infection, providing insight into tandem kinase\u2010mediated immunity and a framework for improving durable stripe rust resistance in wheat.\n                  <\/jats:p>","DOI":"10.1111\/ppl.71103","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:30:32Z","timestamp":1789601432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tandem Kinase\n                    <scp>WTK1<\/scp>\n                    Triggers Waves of Transcriptional Reprogramming Underlying Wheat Resistance to Stripe Rust"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-902X","authenticated-orcid":false,"given":"Liubov","family":"Govta","sequence":"first","affiliation":[{"name":"The Department of Evolutionary and Environmental Biology University of Haifa  Haifa Israel"},{"name":"Institute of Evolution University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6850-6911","authenticated-orcid":false,"given":"Nikolai","family":"Govta","sequence":"additional","affiliation":[{"name":"The Department of Evolutionary and Environmental Biology University of Haifa  Haifa Israel"},{"name":"Institute of Evolution University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4878-930X","authenticated-orcid":false,"given":"Evgenii","family":"Potapenko","sequence":"additional","affiliation":[{"name":"The Department of Evolutionary and Environmental Biology University of Haifa  Haifa Israel"},{"name":"Institute of Evolution University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-4376","authenticated-orcid":false,"given":"Hanan","family":"Sela","sequence":"additional","affiliation":[{"name":"The Department of Evolutionary and Environmental Biology University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-2449","authenticated-orcid":false,"given":"Gitta","family":"Coaker","sequence":"additional","affiliation":[{"name":"The Department of Plant Pathology University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-0040","authenticated-orcid":false,"given":"Tzion","family":"Fahima","sequence":"additional","affiliation":[{"name":"The Department of Evolutionary and Environmental Biology University of Haifa  Haifa Israel"},{"name":"Institute of Evolution University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Gene Set Enrichment Analysis With topGO","volume":"27","author":"Alexa A.","year":"2009","journal-title":"Bioconductor Improvment"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3389\/fpls.2017.01057","article-title":"Yellow Rust Epidemics Worldwide Were Caused by Pathogen Races From Divergent Genetic Lineages","volume":"8","author":"Ali S.","year":"2017","journal-title":"Frontiers in Plant Science"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2023.108032","article-title":"ROS Interplay Between Plant Growth and Stress Biology: Challenges and Future Perspectives","volume":"203","author":"Ali S.","year":"2023","journal-title":"Plant Physiology and Biochemistry"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/genes9070339","article-title":"Disease Resistance Mechanisms in Plants","volume":"9","author":"Andersen E. 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