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In addition to regulating the turnover and structural arrangement of collagen and other proteins of the extracellular matrix, fibroblasts perform a number of specialized functions. Certain fibroblast subpopulations in the gingiva, oral mucosa and periodontal ligament serve as progenitor cells with multilineage differentiation and self\u2010renewal characteristics. In the periodontal ligament, fibroblasts further appear to function as mechanosensing entities that regulate collagen\u2010secretory and collagen\u2010remodeling activities according to the level of strain in the ligament. Mechanical challenge also plays an important role during the activation of periodontal fibroblasts in response to injury. Dysregulation of this activation process can lead either to poor healing and chronic wounds or to overly healed wounds with fibrosis. This review will elaborate on the roles of mechanical factors and mechanoperception in fibroblast activation, the molecular features of activated fibroblasts and the regulation mechanisms of fibroblast contraction. Pharmacological interference at each level is currently being pursued to improve the outcome of healing of injured periodontal tissue.<\/jats:p>","DOI":"10.1111\/prd.12030","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:24:01Z","timestamp":1376281441000},"page":"14-28","source":"Crossref","is-referenced-by-count":85,"title":["Matrix mechanics and regulation of the fibroblast 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