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Together these tissues are defined by the molecules expressed by the resident periodontal cells in each compartment and this determines not only the structure and function of the periodontium but also how it responds to infection and inflammation. The biological activity of these molecules is tightly regulated in time and space to preserve tissue homeostasis, influence inflammatory responses and participate in tissue regeneration. In this issue of <jats:italic>Periodontology 2000<\/jats:italic> we explore new experimental approaches and data sets which help to understand the molecules and cells that regulate tissue form and structure in health, disease and regeneration.<\/jats:p>","DOI":"10.1111\/prd.12037","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:24:01Z","timestamp":1376281441000},"page":"7-13","source":"Crossref","is-referenced-by-count":11,"title":["Information generation and processing systems that regulate periodontal structure and function"],"prefix":"10.1111","volume":"63","author":[{"given":"P. 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