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The assessment of their significance continues to grow rapidly as the complex biology of various chronic inflammatory conditions is better dissected. Increasing evidence strongly links inflammasomes and host\u2010derived small \u2018danger molecule <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2019 signaling with the modulation of the host immune response by microbial colonizers as well as with potential altering of the microbiome structure and intermicrobial interactions in the host. All of these factors eventually lead to the destructive chronic inflammatory disease state. In the oral cavity, a highly dynamic and multifaceted interplay takes place between the signaling of endogenous danger molecules and colonizing microbes on the mucosal surfaces. This interaction may redirect the local microenvironment to favor the conversion of the resident microbiome toward pathogenicity. This review outlines the major components of the known inflammasome complexes\/mechanisms and highlights their regulation, in particular, by oral microorganisms, in relation to periodontal disease pathology. Better characterization of the cellular and molecular biology of the inflammasome will probably identify important potential therapeutic targets for the treatment and prevention of periodontal disease, as well as for other debilitating chronic diseases.<\/jats:p>","DOI":"10.1111\/prd.12084","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T21:04:16Z","timestamp":1438981456000},"page":"83-95","source":"Crossref","is-referenced-by-count":54,"title":["The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity"],"prefix":"10.1111","volume":"69","author":[{"given":"\u00d6zlem","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu 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