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This volume of<jats:italic>Periodontology 2000<\/jats:italic>discusses the multiple facets of a transition from therapeutic empiricism during the late 1960s, toward regenerative therapies, which is founded on a clearer understanding of the biophysiology of normal structure and function. This introductory article provides an overview on the requirements of appropriate<jats:italic>in vitro<\/jats:italic>laboratory models (e.g. cell culture), of preclinical (i.e. animal) models and of human studies for periodontal wound and bone repair. Laboratory studies may provide valuable fundamental insights into basic mechanisms involved in wound repair and regeneration but also suffer from a unidimensional and simplistic approach that does not account for the complexities of the<jats:italic>in vivo<\/jats:italic>situation, in which multiple cell types and interactions all contribute to definitive outcomes. Therefore, such laboratory studies require validatory research, employing preclinical models specifically designed to demonstrate proof\u2010of\u2010concept efficacy, preliminary safety and adaptation to human disease scenarios. Small animal models provide the most economic and logistically feasible preliminary approaches but the outcomes do not necessarily translate to larger animal or human models. The advantages and limitations of all periodontal\u2010regeneration models need to be carefully considered when planning investigations to ensure that the optimal design is adopted to answer the specific research question posed. Future challenges lie in the areas of stem cell research, scaffold designs, cell delivery and choice of growth factors, along with research to ensure appropriate gingival coverage in order to prevent gingival recession during the healing phase.<\/jats:p>","DOI":"10.1111\/prd.12091","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T08:28:19Z","timestamp":1428913699000},"page":"7-20","source":"Crossref","is-referenced-by-count":78,"title":["Wound models for periodontal and bone regeneration: the role of biologic research"],"prefix":"10.1111","volume":"68","author":[{"given":"Anton","family":"Sculean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain L. 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