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A recent study of centenarians found that at age 65\u201374\u00a0years, those who lived to be 100 had a lower rate of edentulism than did younger members of their birth cohort at ages 65\u201374\u00a0years. Oral health was consistent with compression of morbidity toward the end of life. This article explores the hypothesis that factors associated with oral disease and noncommunicable diseases may increase the risk of tooth loss and lead to diminished longevity as a result of multifactorial interactions. It specifically addresses two critical questions. The first is: \u2018Can we conclude that the number of teeth in aging humans can affect longevity and life expectancy?\u2019 The answer is yes. The second is: \u2018Is tooth loss a predictor of shortened longevity?\u2019 Again, the answer is yes. Edentulism and partial edentulism are discussed as a disability, and how the philosophy\/belief systems of dental providers and patients toward retaining teeth influences the outcome of tooth loss is also examined. Osteoporosis and cognitive impairment provide examples of modifying risk factors.<\/jats:p>","DOI":"10.1111\/prd.12128","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T18:35:06Z","timestamp":1470681306000},"page":"142-152","source":"Crossref","is-referenced-by-count":79,"title":["Tooth loss as a predictor of shortened longevity: exploring the hypothesis"],"prefix":"10.1111","volume":"72","author":[{"given":"Paula K.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira B.","family":"Lamster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01949.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2009.00311.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr223"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.138327"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068592"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.03.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1695-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.2009.00132.x"},{"key":"e_1_2_8_11_1","unstructured":"Centers for Disease Control and Prevention.National Center for Health Statistics. 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