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This war clearly signifies many \u2018battlefronts\u2019 representing the interface of the mucosal\u2010surface cells with the dynamic biofilms composed of commensal and potential pathogenic species, as well as more recent knowledge demonstrating active invasion of cells and tissues of the periodontium leading to skirmishes in connective tissue, the locality of bone and even in the local vasculature. Research in the discipline has uncovered a concerted effort of the microbiome, using an array of survival strategies, to interact with other bacteria and host cells. These strategies aid in colonization by \u2018ambushing, infiltrating and outflanking\u2019 host cells and molecules, responding to local environmental changes (including booby traps for host biomolecules), communicating within and between genera and species that provide<jats:styled-content style=\"fixed-case\">MASINT<\/jats:styled-content>(Measurement and Signature Intelligence) to enhance sustained survival, sabotage the host inflammatory and immune responses and by potentially adopting a \u2018Fabian strategy\u2019 with a war of attrition and resulting disease manifestations. Additionally, much has been learned regarding the ever\u2010increasing complexity of the host\u2010response armamentarium at both cellular and molecular levels that is addressed in this review. Knowledge regarding how these systems fully interact requires both new laboratory and clinical tools, as well as sophisticated modeling of the networks that help maintain homeostasis and are dysregulated in disease. Finally, the triggers resulting in a \u2018coup de main\u2019 by the microbiome (exacerbation of disease) and the characteristics of susceptible hosts that can result in \u2018pyrrhic victories\u2019 with collateral damage to host tissues, the hallmark of periodontitis, remains unclear. While much has been learned, substantial gaps in our understanding of the \u2018parameters of this war\u2019 remain elusive toward fulfilling the Sun Tzu adage: \u2018If you know the enemy and know yourself, you need not fear the result of a hundred battles.\u2019<\/jats:p>","DOI":"10.1111\/prd.12222","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T07:25:33Z","timestamp":1501485933000},"page":"52-115","source":"Crossref","is-referenced-by-count":186,"title":["The periodontal war: microbes and immunity"],"prefix":"10.1111","volume":"75","author":[{"given":"Jeffrey L.","family":"Ebersole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Dolph","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Emecen\u2010Huja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Peyyala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al\u2010Attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Lethbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenatha","family":"Kirakodu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio A.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.68"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01464.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2000.150108.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-016-1223-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46569-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12210"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01445.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v24.i3.20"},{"key":"e_1_2_8_11_1","unstructured":"AmadorB SorensonH KnowltonA WalletS.Oral epithelial cell control of immune plasticity in periodontal disease. 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