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It is now said that an implant is regarded as osseointegrated when there is no progressive relative movement between the implant and the bone with which it is in direct contact. Although the term osseointegration was initially used with reference to titanium metallic implants, the concept is currently applied to all biomaterials that have the ability to osseointegrate. Biomaterials are closely related to the mechanism of osseointegration; these materials are designed to be implanted or incorporated into the living system with the aims to substitute for, or regenerate, tissues and tissue functions. Objective evaluation of the properties of the different biomaterials and of the factors that influence bone repair in general, and at the bone tissue\u2013implant interface, is essential to the clinical success of an implant. The Biomaterials Laboratory of the Oral Pathology Department of the School of Dentistry at the University of Buenos Aires is devoted to the study and research of the properties and biological effects of biomaterials for dental implants and bone substitutes. This paper summarizes the research work resulting from over 25\u00a0years\u2019 experience in this field. It includes studies conducted at our laboratory on the local and systemic factors affecting the peri\u2010implant bone healing process, using experimental models developed by our research team. The results of our research on corrosion, focusing on dental implants, as well as our experience in the evaluation of failed dental implants and bone biopsies obtained following maxillary sinus floor augmentation with bone substitutes, are also reported. Research on biomaterials and their interaction with the biological system is a continuing challenge in biomedicine, which aims to achieve optimal biocompatibility and thus contribute to patient health.<\/jats:p>","DOI":"10.1111\/prd.12254","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T06:23:50Z","timestamp":1553063030000},"page":"178-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":274,"title":["Research on implants and osseointegration"],"prefix":"10.1111","volume":"79","author":[{"given":"Mar\u00eda B.","family":"Guglielmotti","sequence":"first","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"National Research Council (CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Olmedo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"National Research Council (CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3mulo L.","family":"Cabrini","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"Department of Radiobiology National Atomic Energy Commission Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(83)80101-2"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"175","article-title":"Osseointegration in skeletal reconstruction and rehabilitation: a review","volume":"38","author":"Br\u00e5nemark R","year":"2001","journal-title":"J Rehabil Res Dev."},{"issue":"10","key":"e_1_2_9_4_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. 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