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Research has paved the way for a greater understanding of the periodontal microbiome, improvement in periodontal diagnostics and therapies, and the recognition of periodontitis being associated with more than 50 systemic diseases. The etiopathology of progressive periodontitis includes active herpesviruses, specific bacterial pathogens, and proinflammatory immune responses. This article points to a role of periodontal herpesviruses in the development of systemic diseases and proposes treatment of severe periodontitis not only to avoid tooth loss, but also to reduce the risk for systemic diseases. An efficient, safe, and reliable anti\u2010infective treatment of severe periodontitis is presented, which targets both herpesviruses and bacterial pathogens and which can be carried out in minimal time with minimal cost.<\/jats:p>","DOI":"10.1111\/prd.12258","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T10:23:50Z","timestamp":1553077430000},"page":"233-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Focal infection of periodontal origin"],"prefix":"10.1111","volume":"79","author":[{"given":"J\u00f8rgen","family":"Slots","sequence":"first","affiliation":[{"name":"Division of Periodontology Diagnostic Sciences and Dental Hygiene Ostrow School of Dentistry of USC University of Southern California Los Angeles California 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