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There is considerable evidence that oral lesions\/disorders such as some leukoplakias, most erythroplakias, and submucous fibrosis have malignant potential, with a conversion rate of 5%\u201010% over a 10\u2010year period. There have been several reports on possible biomarkers that predict malignant conversion of the oral lesions associated with these disorders. Management of these is mostly surgical removal of the lesion followed by observation, and in some cases treatment by antioxidants and anti\u2010inflammatory agents. Oral submucous fibrosis is due to excessive deposition of extracellular matrix in the connective tissue plus, particularly, collagens. The deposition of collagen leads to stiffness of the affected regions and results in difficulty in mouth opening. Areca nut chewing is proposed as the most probable etiological factor in the manifestation of oral submucous fibrosis. Several studies suggest involvement of proinflammatory cytokines, dysregulated by areca nut, in the development of the disease. Amongst these, transforming growth factor\u2010\u03b2 is in the forefront, which is also shown to be involved in fibrosis of other organs. This review addresses the molecular mechanisms involved in oral submucous fibrosis development and provides a model for the regulation of transforming growth factor\u2010\u03b2 by areca nut. It provides an exemplar of the role of modern molecular techniques in the study of oral disease.<\/jats:p>","DOI":"10.1111\/prd.12266","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T07:51:53Z","timestamp":1557906713000},"page":"213-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis"],"prefix":"10.1111","volume":"80","author":[{"given":"Paturu","family":"Kondaiah","sequence":"first","affiliation":[{"name":"Department of Molecular Reproduction, Development and Genetics Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ila","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences Icahn School of Medicine at Mount Sinai  New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Khan","sequence":"additional","affiliation":[{"name":"Women's Malignancies Branch NCI National Institute of Health (NIH)  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12277"},{"key":"e_1_2_15_3_1","first-page":"171","article-title":"Submucous fibrosis of the palate in diet\u2010preconditioned Wistar rats. 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