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In 2012, during the Consensus Report from the Joint <jats:styled-content style=\"fixed-case\">EFP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AAP<\/jats:styled-content> workshop on periodontitis and systematic diseases the role of periodontal diseases on <jats:styled-content style=\"fixed-case\">APO<\/jats:styled-content>s was reviewed. Some years later, this evidence has grown, and an update on the literature regarding the mechanisms related to this potential association (<jats:styled-content style=\"fixed-case\">APO<\/jats:styled-content>s and periodontal diseases) needs to be presented. The two major pathways (direct and indirect) already accepted in 2012 are still valid nowadays. Most evidence published in the last 5\u00a0years deals with a strong and solid evidence coming from the direct pathway while there is as scarce new evidence regarding indirect pathway. In this direct pathway, the haematological dissemination of oral microorganisms and their products, would later induce an inflammatory\/Immune response in the foetal\u2010placental unit. The most plausible route for this direct pathway is the hematogenous transmission through dental bacteremia, although not many new studies dealing with bacteremia has been performed lately.<\/jats:p>","DOI":"10.1111\/prd.12295","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:41:36Z","timestamp":1589002896000},"page":"175-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Periodontal diseases and adverse pregnancy outcomes: Mechanisms"],"prefix":"10.1111","volume":"83","author":[{"given":"Elena","family":"Figuero","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group Department of Dental Clinical Specialties Faculty of Dentistry University Complutense of Madrid (UCM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping 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