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In addition, host\u2010pathogen interactions related to the oropharyngeal microbiome or its metabolites could propagate systemic inflammation or modulate host defense mechanisms that could affect other organs, including the lung. There is increasing appreciation of the pathophysiologic significance of the lung microbiome, not only in the classical infection\u2010related diseases, pneumonia, bronchiectasis, and cystic fibrosis, but also in chronic noninfectious lung diseases, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. In this review, we will explore the relationship of the oral microbiome with lung diseases, such as pneumonia, chronic obstructive pulmonary disease, asthma, and cystic fibrosis.<\/jats:p>","DOI":"10.1111\/prd.12301","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:34:42Z","timestamp":1589002482000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Oral\u2010lung microbiome interactions in lung diseases"],"prefix":"10.1111","volume":"83","author":[{"given":"Manoj J.","family":"Mammen","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Jacobs School of Medicine University at Buffalo, State University of New York Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Scannapieco","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental Medicine University at Buffalo, State University of New York Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Sethi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Jacobs School of Medicine University at Buffalo, State University of New York Buffalo New York USA"},{"name":"Veterans Affairs Western New York Healthcare System Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2012.00928.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272427"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200305000-00002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.251"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00037-15"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1913OC"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","unstructured":"SegalLN. 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