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This article evaluates the pathogenicity of herpesviruses (cytomegalovirus and Epstein\u2010Barr virus) and periodontopathic bacteria (<jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>and<jats:italic>Porphyromonas gingivalis<\/jats:italic>) and coinfection of these infectious agents in the initiation and progression of periodontitis. Cytomegalovirus and<jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>\/<jats:italic>P. gingivalis<\/jats:italic>exercise synergistic pathogenicity in the development of localized (\u201caggressive\u201d) juvenile periodontitis. Cytomegalovirus and Epstein\u2010Barr virus are associated with<jats:italic>P. gingivalis<\/jats:italic>in adult types of periodontitis. Periodontal herpesviruses that enter the general circulation may also contribute to disease development in various organ systems. A 2\u2010way interaction is likely to occur between periodontal herpesviruses and periodontopathic bacteria, with herpesviruses promoting bacterial upgrowth, and bacterial factors reactivating latent herpesviruses. Bacterial\u2010induced gingivitis may facilitate herpesvirus colonization of the periodontium, and herpesvirus infections may impede the antibacterial host defense and alter periodontal cells to predispose for bacterial adherence and invasion. Herpesvirus\u2010bacteria synergistic interactions, are likely to comprise an important pathogenic determinant of aggressive periodontitis. However, mechanistic investigations into the molecular and cellular interaction between periodontal herpesviruses and bacteria are still scarce. Herpesvirus\u2010bacteria coinfection studies may yield significant new discoveries of pathogenic determinants, and drug and vaccine targets to minimize or prevent periodontitis and periodontitis\u2010related systemic diseases.<\/jats:p>","DOI":"10.1111\/prd.12311","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T10:57:25Z","timestamp":1576666645000},"page":"42-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Herpesvirus\u2010bacteria synergistic interaction in periodontitis"],"prefix":"10.1111","volume":"82","author":[{"given":"Casey","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Periodontology, Diagnostic Sciences &amp; Dental Hygiene Herman Ostrow School of Dentistry University of Southern California Los Angeles California 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