{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:39Z","timestamp":1788870519020,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontology is an infectious disease\u2010based discipline. The etiopathology of progressive\/severe periodontitis includes active herpesviruses, specific bacterial pathogens, and proinflammatory cytokines. Herpesviruses and periodontopathic bacteria may interact synergistically to produce periodontal breakdown, and periodontal herpesviruses may contribute to systemic diseases. The infectious agents of severe periodontitis reside in deep pockets, furcation lesions, and inflamed gingiva, sites inaccessible by conventional (purely mechanical) surgical or nonsurgical therapy but accessible by systemic antibiotic treatment. This brief overview presents an effective anti\u2010infective treatment of severe periodontitis, which includes systemic chemotherapy\/antibiotics against herpesviruses (valacyclovir [acyclovir]) and bacterial pathogens (amoxicillin\u00a0+\u00a0metronidazole or ciprofloxacin\u00a0+\u00a0metronidazole) plus common antiseptics (povidone\u2010iodine and sodium hypochlorite) and select ultrasonic scaling. The proposed treatment can cause a marked reduction or elimination of major periodontal pathogens, is acceptably safe, and can be carried out in minimal time with minimal cost.<\/jats:p>","DOI":"10.1111\/prd.12325","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:34:42Z","timestamp":1589002482000},"page":"272-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Primer on etiology and treatment of progressive\/severe periodontitis: A systemic health perspective"],"prefix":"10.1111","volume":"83","author":[{"given":"J\u00f8rgen","family":"Slots","sequence":"first","affiliation":[{"name":"Ostrow School of Dentistry University of Southern California Los Angeles CA 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