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The use of sustained\u2010release delivery systems, applied locally to the periodontal pocket, seems to be one feasible approach: local sustained\u2010release delivery of antibacterial agents to treat periodontal diseases is conceivable. The use of local (intrapocket) sustained\u2010release delivery systems has numerous clinical, pharmacologic, and toxicologic advantages over conventional treatments for periodontal diseases. Sustained\u2010release technology has been proven to be effective over the last few decades. Films, gels, and fibers are the three main classical intrapocket pharmaceutical delivery systems. Research today is more focused on improving drug delivery, and less on introducing new drugs. New approaches, eg, those making use of nanotechnology, are emerging for local drug\u2010delivery systems. The local sustained\u2010release delivery system concept is innovative and a few products are already commercially available.<\/jats:p>","DOI":"10.1111\/prd.12341","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T14:40:52Z","timestamp":1598452852000},"page":"176-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Sustained\u2010release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?"],"prefix":"10.1111","volume":"84","author":[{"given":"Doron","family":"Steinberg","sequence":"first","affiliation":[{"name":"Biofilm Research Laboratory Faculty of Dental Medicine Institute of Dental Sciences The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedman","sequence":"additional","affiliation":[{"name":"School of Pharmacy The Institute for Drug 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