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Although the epidemiologic evidence for an association between these two diseases is still scarce, there is emerging scientific information linking specific bacterial periodontal pathogens, such as\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Aggregatibacter actinomycetemcomitans,<\/jats:italic>\n                    in the citrullination process, leading to autoantibody formation and compromised immunotolerance of the susceptible patient to rheumatoid arthritis. In this review, we update the existing information on the evidence, not only regarding the epidemiologic association, but also the biologic mechanisms linking these two diseases. Finally, we review information emerging from intervention studies evaluating whether periodontal treatment could influence the initiation and progression of rheumatoid arthritis.\n                  <\/jats:p>","DOI":"10.1111\/prd.12385","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T11:39:40Z","timestamp":1630409980000},"page":"181-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?"],"prefix":"10.1111","volume":"87","author":[{"given":"Jeri\u00e1n","family":"Gonz\u00e1lez\u2010Febles","sequence":"first","affiliation":[{"name":"Departament of Dental Clinical Specialties Faculty of Odontology University Complutense Madrid Spain"},{"name":"Research Group on the Aetiology and Treatment of Periodontal and Periimplant Diseases (ETEP) Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Departament of Dental Clinical Specialties Faculty of Odontology University Complutense Madrid Spain"},{"name":"Research Group on the Aetiology and Treatment of Periodontal and Periimplant Diseases (ETEP) Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.8.722"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24092"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184541"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.8.735"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"535","article-title":"Prevalence of rheumatic diseases in adult population in Spain. 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