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These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause\u2010and\u2010effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis\u2010systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis\u2010linked comorbidities.<\/jats:p>","DOI":"10.1111\/prd.12430","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T09:36:20Z","timestamp":1646386580000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":423,"title":["Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications"],"prefix":"10.1111","volume":"89","author":[{"given":"George","family":"Hajishengallis","sequence":"first","affiliation":[{"name":"Department of Basic and Translational Sciences Penn Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania 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