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Recent studies have indicated that the classical viewpoint of the immunological processes underpinning the pathobiology of rheumatoid arthritis is restricted and needs to be expanded to include a more holistic and interdisciplinary approach incorporating bacteria\u2010induced inflammatory reactions as an important pathway in rheumatoid arthritis etiology. Here, we discuss in detail data showing the clinical and molecular association of rheumatoid arthritis development with periodontal diseases. We also describe the unique role of periopathogens, which have been proposed to be crucial in the initiation and progression of this autoimmune pathological disorder.<\/jats:p>","DOI":"10.1111\/prd.12432","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T09:39:35Z","timestamp":1646818775000},"page":"83-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Pros and cons of causative association between periodontitis and rheumatoid arthritis"],"prefix":"10.1111","volume":"89","author":[{"given":"Joanna","family":"Koziel","sequence":"first","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Potempa","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry, Biophysics and 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