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From the host's perspective, lipopolysaccharide plays a role in both local and systemic inflammation, activates both innate and adaptive immunity, and can trigger inflammation either directly (as a microbe\u2010associated molecular pattern) or indirectly (by inducing the generation of nonmicrobial, danger\u2010associated molecular patterns). Translocation of lipopolysaccharide into the circulation causes endotoxemia, which is typically measured as the biological activity of lipopolysaccharide to induce coagulation of an aqueous extract of blood cells of the assay. Apparently healthy subjects have a low circulating lipopolysaccharide activity, since it is neutralized and cleared rapidly. However, chronic endotoxemia is involved in the pathogenesis of many inflammation\u2010driven conditions, especially cardiometabolic disorders. These include atherosclerotic cardiovascular diseases, obesity, liver diseases, diabetes, and metabolic syndrome, where endotoxemia has been recognized as a risk factor. The main source of endotoxemia is thought to be the gut microbiota. However, the oral dysbiosis in periodontitis, which is typically enriched with gram\u2010negative bacterial species, may also contribute to endotoxemia. As endotoxemia is associated with an increased risk of cardiometabolic disorders, lipopolysaccharide could be considered as a molecular link between periodontal microbiota and cardiometabolic diseases.<\/jats:p>","DOI":"10.1111\/prd.12433","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T14:29:47Z","timestamp":1646404187000},"page":"19-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia"],"prefix":"10.1111","volume":"89","author":[{"given":"Pirkko J.","family":"Pussinen","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Kopra","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla","family":"Pieti\u00e4inen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Lehto","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics Folkh\u00e4lsan Research Center  Helsinki Finland"},{"name":"Abdominal Center, Nephrology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Clinical and Molecular Metabolism Faculty of Medicine Research Programs University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetislav","family":"Zaric","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral &amp; Craniofacial Sciences Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Paju","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Salminen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3703-3713.1999"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1491"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02418.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.138743"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.1.6.684-688.1994"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.21.6.865-868.1985"},{"key":"e_1_2_10_9_1","unstructured":"KallioE.Lipopolysaccharide: a link between periodontitis and cardiometabolic disorders. 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