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However, this notion has been challenged over the past decade by proponents of a theory that considers osseointegration an inflammatory process characterized by a foreign body reaction and peri\u2010implant bone loss as an exacerbation of this inflammatory response. A key difference in these two schools of thought is the perception of the relative importance of dental plaque in the pathogenesis of crestal bone loss around implants, with obvious implications for treatment. This review investigates the evidence for a persistent foreign body reaction at osseointegrated dental implants and its possible role in crestal bone loss characteristic of peri\u2010implantitis. Further, the role of implant\u2010related material release within the surrounding tissue, particularly titanium particles and corrosion by\u2010products, in the establishment and progression in peri\u2010implantitis is explored. While it is acknowledged that these issues require further investigation, the available evidence suggests that osseointegration is a state of homeostasis between the titanium implant and surrounding tissues, with little evidence that a persistent foreign body reaction is responsible for peri\u2010implant bone loss after osseointegration is established. Further, there is a lack of evidence for a unidirectional causative role of corrosion by\u2010products and titanium particles as possible non\u2013plaque related factors in the etiology of peri\u2010implantitis.<\/jats:p>","DOI":"10.1111\/prd.12456","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T19:46:47Z","timestamp":1659469607000},"page":"176-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The role of foreign body response in <scp>peri\u2010implantitis<\/scp>: What is the evidence?"],"prefix":"10.1111","volume":"90","author":[{"given":"Sa\u0161o","family":"Ivanovski","sequence":"first","affiliation":[{"name":"School of Dentistry The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Mark","family":"Bartold","sequence":"additional","affiliation":[{"name":"School of Dentistry University of 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