{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:25:10Z","timestamp":1793985910523,"version":"4.8.0"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to compare patient\u2010reported outcome measures (PROMs) of soft tissue substitutes versus autogenous grafts for soft tissue augmentation procedures at implant sites. Comprehensive and systematic literature searches were performed until December 2021. A focused question was formulated based on the Population, Intervention, Comparison and Outcome criteria (PICO): In patients with dental implants undergoing soft tissue augmentation (P), do soft tissue substitutes (I) compared to autogenous soft tissue graft (SCTG [subepithelial connective tissue graft]) (C) limit the post\u2010operative morbidity and other patient reported\u2010outcomes measures (O). Randomized controlled clinical trials, prospective\u2010, retrospective\u2010 and case\u2010series studies were included. Meta\u2010analyses were performed whenever possible and the results were expressed as weighted mean differences (WMD). A total of 29 clinical studies were included. For mucosal thickness gain, soft tissue substitutes significantly reduced the pain perception compared to SCTG (n\u00a0=\u00a04; WMD\u00a0=\u00a014.91 Visual Analog Scale [VAS] units; 95% confidence interval [CI] 6.42\u201023.40;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.0006) based on a 0\u2010100 VAS scale. Based on a 0\u201010 VAS scale, a borderline significance of pain reduction was found when soft tissue substitutes were applied (n\u00a0=\u00a04; WMD\u00a0=\u00a01.62 VAS units; 95% CI 0.01\u20103.23;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.05). For keratinized tissue gain, soft tissue substitutes significantly reduced the pain perception after keratinized tissue augmentation compared to SCTG based on a 0\u2010100 VAS scale (n\u00a0=\u00a02; WMD\u00a0=\u00a021.43 VAS units; 95% CI 12.58\u201030.28;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.0001). Based on the 0\u201010 VAS scale, soft tissue substitutes significantly reduced the pain as compared to SCTG (n\u00a0=\u00a04; WMD\u00a0=\u00a01.65 VAS units; 95% CI 0.66\u20102.64;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.001). Regarding pain medication, soft tissue substitutes required less painkillers (n\u00a0=\u00a06; WMD\u00a0=\u00a01.56 tablets; 95% CI 1.22\u20101.91;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.00001) after soft tissue augmentation. The surgery time was significantly reduced when soft tissue substitutes were used (n\u00a0=\u00a05; WMD\u00a0=\u00a010.9\u00a0minutes; 95% CI 4.60\u201017.19;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.00001). There were no significant differences in satisfaction, aesthetics, and quality of life (OHIP\u201014) between soft tissue substitutes and autogenous grafts following soft tissue augmentation at implants sites. Soft tissue substitutes, compared to autogenous grafts, significantly improve PROMs following soft tissue augmentation at implant sites. Soft tissue substitutes can reduce pain perception, amounts of painkillers and surgery time while achieving similar levels of patient\u00b4s satisfaction as autogenous grafts without impairing the clinical outcomes. The current evidence indicates that they constitute a valid and reliable alternative to minimize the invasiveness in soft tissue augmentation procedures at implant sites.\n                  <\/jats:p>","DOI":"10.1111\/prd.12465","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T07:45:40Z","timestamp":1660203940000},"page":"182-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Minimal invasiveness in soft tissue augmentation at dental implants: A systematic review and meta\u2010analysis of patient\u2010reported outcome measures"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"first","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7327","authenticated-orcid":false,"given":"Franz J.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-155X","authenticated-orcid":false,"given":"Leonardo","family":"Mancini","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-6065","authenticated-orcid":false,"given":"Thomas J. W.","family":"Gasser","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12563"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0471"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13114"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0716"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120688"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-2007-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13798"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0350"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12185"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12287"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01550.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13196"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13194"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7497"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145043"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12215"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350611426011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.225202edi01"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12634"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13299"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02972-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01841.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0131"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130693"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0627"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12983"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1465312519840032"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140574"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13767"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.15.1814"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_34_1","unstructured":"HigginsJPT TJ ChandlerJ CumpstonM LiT PageMJ WelchVA eds.Cochrane Handbook for Systematic Reviews of Interventions version 6.2.2021.www.training.cochrane.org\/handbook. 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