{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:37:35Z","timestamp":1788910655343,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Localized juvenile (aggressive) periodontitis starts at puberty in otherwise healthy individuals and involves the proximal surfaces of permanent incisors and first molars. The disease destroys a sizeable amount of periodontal bone within a few months despite minimal dental plaque and gingival tissue inflammation. Cytomegalovirus and Epstein\u2013Barr virus, as well as the two main periodontopathic bacteria\n                    <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                    and\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , are linked to juvenile periodontitis. Juvenile periodontitis\u2010affected teeth show cementum hypoplasia. We hypothesize that an active herpesvirus infection, at the time of root formation, hampers cementum formation and, at puberty, herpesvirus reactivation triggers an upgrowth of bacterial pathogens which produce rapid periodontal destruction on teeth with a defective periodontium. A pathogenic interaction between active herpesviruses and bacterial pathogens can potentially explain the etiology and incisor\u2010first molar destructive pattern of juvenile periodontitis. Effective treatment of juvenile periodontitis may target the herpesvirus\u2010bacteria co\u2010infection.\n                  <\/jats:p>","DOI":"10.1111\/prd.12501","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T10:06:56Z","timestamp":1687601216000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<scp>Herpesvirus\u2010Bacteria<\/scp>\n                    pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease"],"prefix":"10.1111","volume":"94","author":[{"given":"J\u00f8rgen","family":"Slots","sequence":"first","affiliation":[{"name":"Division of Periodontology and Diagnostic Sciences University of Southern California School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Rams","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, and Oral Microbiology Testing Service Laboratory Temple University School of Dentistry  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12085"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.1999.140402.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12311"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280804.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0279"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.11.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12258"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12221"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12435"},{"key":"e_1_2_9_12_1","first-page":"2479","volume-title":"Fields virology","author":"Pellett PE","year":"2007"},{"key":"e_1_2_9_13_1","first-page":"188","volume-title":"Textbook of Clinical Periodontology","author":"Lindhe J","year":"1983"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.981"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.10.1460"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00729-13"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186373"},{"key":"e_1_2_9_19_1","unstructured":"RamsTE ContrerasA SlotsJ.Aggressive periodontitis in southwestern American Indian adolescents. 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