{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:57:15Z","timestamp":1791446235751,"version":"4.3.3"},"reference-count":367,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient's risk factors and the debridement of supra and subgingival biofilm. This debridement can be performed with or without the use of some adjuvant therapies, including physical or chemical agents, host modulating agents, subgingivally locally delivered antimicrobials, or systemic antimicrobials. Therefore, the main aim of this article is to review in a narrative manner the existing literature regarding the adjuvant application of local agents, either subgingivally delivered antibiotics and antiseptics or supragingivally applied rinses and dentifrices, during the different steps in periodontal therapy performed in Europe.<\/jats:p>","DOI":"10.1111\/prd.12511","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:25:39Z","timestamp":1695885939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Supra and subgingival application of antiseptics or antibiotics during periodontal therapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"first","affiliation":[{"name":"Department of Dental Clinical Specialties, Etiology and Therapy of Periodontal and Peri\u2010implant Research Group, Faculty of Dentistry University Complutense of Madrid Madrid Spain"},{"name":"Etiology and Therapy of Periodontal and Peri\u2010implant Research Group University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-0360","authenticated-orcid":false,"given":"Jorge","family":"Serrano","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010implant Research Group University Complutense of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1453-0697","authenticated-orcid":false,"given":"Nicole Birgit","family":"Arweiler","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Peri\u2010implant Diseases Philipps University of Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten Mathias","family":"Auschill","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Peri\u2010implant Diseases Philipps University of Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-5689","authenticated-orcid":false,"given":"Ali","family":"G\u00fcrkan","sequence":"additional","affiliation":[{"name":"Department of Peridontology Ege University School of Dentistry Bornova Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-9629","authenticated-orcid":false,"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Peridontology Ege University School of Dentistry Bornova 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