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Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and\/or late complications related to the stability of the peri\u2010implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant\u2010related factors, like implant surface or titanium particle release; surgical\u2010related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti\u2010hypertensives, nonsteroidal anti\u2010inflammatory medication, and statins, and host\u2010related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri\u2010implant bone loss. Despite the infectious nature of peri\u2010implant biological complications, these factors must be surveyed for the effective prevention and management of peri\u2010implantitis.<\/jats:p>","DOI":"10.1111\/prd.12532","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:55:52Z","timestamp":1698713752000},"page":"27-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Emerging factors affecting peri\u2010implant bone metabolism"],"prefix":"10.1111","volume":"94","author":[{"given":"Angel","family":"Insua","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine University of Michigan  Ann Arbor Michigan 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