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The benefits of APCs are largely influenced by the treatment strategy but also their preparation. This paper therefore discusses in detail: the physical properties of blood cells, the basic principles of blood centrifugation, the impact of the centrifugation protocol (rotations\/revolutions per minute, g\u2010force, variation between centrifuges), the importance of timing during the preparation of APCs, the impact of the inner surface of the blood tubes, the use\/nonuse of anticoagulants within APC tubes, the impact of the patient's hematocrit, age, and gender, as well as the important requirements for an optimal centrifugation protocol. All these variables indeed have a significant impact on the clinical outcome of APCs.<\/jats:p>","DOI":"10.1111\/prd.12555","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T01:23:22Z","timestamp":1716427402000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Essential principles for blood centrifugation"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-3908","authenticated-orcid":false,"given":"Marc","family":"Quirynen","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven &amp; Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Ahmad Manoetjer","family":"Siawasch","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven &amp; Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jize","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, KU Leuven &amp; Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_16_2_1","first-page":"123","article-title":"Anemia in older adults","volume":"12","author":"Woodman R","year":"2005","journal-title":"Curr Opin Hematol"},{"key":"e_1_2_16_3_1","first-page":"35","article-title":"Etiology of differences in hematocrit between males and females: sequence\u2010based polymorphisms in erythropoietin and its 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