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To ensure an optimal clinical outcome, clinicians must adhere strictly to the protocol to prepare the APCs and, especially follow evidence\u2010based surgical guidelines, often simple but crucial, to minimize the likelihood of errors. The majority of clinical trials reported on second\u2010generation APCs [the leukocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF) family, including its modifications (A\u2010PRF, A\u2010PRF+, CGF, T\u2010PRF, H\u2010PRF, etc.)]. These second\u2010generation APCs offer additional benefits compared to the first\u2010generation APCs, making them the preferred choice for the development of clinical recommendations. These recommendations have been formulated through a meticulous examination of the available clinical data and the clinical experience of the authors of this paper.<\/jats:p>","DOI":"10.1111\/prd.12564","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T04:23:53Z","timestamp":1716870233000},"page":"420-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Instructions for the use of <scp>L\u2010PRF<\/scp> in different clinical indications"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-3908","authenticated-orcid":false,"given":"M.","family":"Quirynen","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, Katholieke Universiteit Leuven, Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-513X","authenticated-orcid":false,"given":"J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Department of Stomatology, Unit of Periodontology Santiago de Compostela University  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-1799","authenticated-orcid":false,"given":"H.\u2010L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, School of Dentistry The University of Michigan  Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-9073","authenticated-orcid":false,"given":"N.","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-2236","authenticated-orcid":false,"given":"A.","family":"Temmerman","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, Katholieke Universiteit Leuven, Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-3113","authenticated-orcid":false,"given":"A.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, Katholieke Universiteit Leuven, Dentistry (Periodontology) University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-3359","authenticated-orcid":false,"given":"N.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Faculty of Medicine Universidad de la Frontera  Temuco Chile"},{"name":"Chairman of Center for Research in Regenerative Medicine and Tissue Engineering  Concepci\u00f3n Chile"},{"name":"Faculty of Dentistry Universidad de Los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12546"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12550"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12570"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12565"},{"key":"e_1_2_10_6_1","first-page":"104","article-title":"Autologous Platelet concentrates (APCs) in alveolar ridge preservation (ARP): a systematic review & meta\u2010analyses","volume":"97","author":"Siawach SAM","year":"2025","journal-title":"Periodontol 2000"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12554"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12604"},{"key":"e_1_2_10_9_1","article-title":"Effect of autogenous platelet concentrates and their centrifugation protocols on the outcomes of root coverage: A systematic review & network meta\u2010analysis","author":"Barootchi S","year":"2024","journal-title":"Periodontol 2000"},{"key":"e_1_2_10_10_1","article-title":"Periodontal regeneration using platelet\u2010rich fibrin. 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