{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:13:04Z","timestamp":1792109584568,"version":"4.4.0"},"reference-count":201,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006389","name":"Universit\u00e9 de Gen\u00e8ve","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED6481B\u20102023\/117"],"award-info":[{"award-number":["ED6481B\u20102023\/117"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201003528"],"award-info":[{"award-number":["2021\u201003528"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201001014"],"award-info":[{"award-number":["2022\u201001014"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010763","name":"Sveriges Ornitologiska F\u00f6rening","doi-asserted-by":"publisher","award":["FoUI\u2010966140"],"award-info":[{"award-number":["FoUI\u2010966140"]}],"id":[{"id":"10.13039\/100010763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010763","name":"Sveriges Ornitologiska F\u00f6rening","doi-asserted-by":"publisher","award":["FoUI\u2010978687"],"award-info":[{"award-number":["FoUI\u2010978687"]}],"id":[{"id":"10.13039\/100010763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Periodontology 2000"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding of subgingival community dynamics. Certain pathobionts can orchestrate the establishment of dysbiotic communities that can subvert the host immune system, triggering inflammation and tissue destruction. Yet, diagnosis and management of periodontal conditions still rely on clinical and radiographic examinations, overlooking the well\u2010established microbial etiology. This review summarizes the chronological emergence of periodontal etiological models and the co\u2010evolution with technological advances in microbial detection. We additionally review the microbial analytical approaches currently accessible to clinicians, highlighting their value in broadening the periodontal assessment. The epidemiological importance of obtaining culture\u2010based antimicrobial susceptibility profiles of periodontal taxa for antibiotic resistance surveillance is also underscored, together with clinically relevant analytical approaches to guide antibiotherapy choices, when necessary. Furthermore, the importance of 16S\u2010based community and shotgun metagenomic profiling is discussed in outlining dysbiotic microbial signatures. Because dysbiosis precedes periodontal damage, biomarker identification offers early diagnostic possibilities to forestall disease relapses during maintenance. Altogether, this review highlights the underutilized potential of clinical microbiology in periodontology, spotlighting the clinical areas most conductive to its diagnostic implementation for enhancing prevention, treatment predictability, and addressing global antibiotic resistance.<\/jats:p>","DOI":"10.1111\/prd.12571","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:07:23Z","timestamp":1716768443000},"page":"176-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Microbial diagnostics in periodontal diseases"],"prefix":"10.1111","volume":"95","author":[{"given":"Daniel","family":"Manoil","sequence":"first","affiliation":[{"name":"Division of Cariology and Endodontics, University Clinics of Dental Medicine, Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Parga","sequence":"additional","affiliation":[{"name":"Division of Cariology and Endodontics, University Clinics of Dental Medicine, Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Department of Microbiology and Parasitology, CIBUS\u2014Faculty of Biology Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6564-9412","authenticated-orcid":false,"given":"Georgios N.","family":"Belibasakis","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02114.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.174"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.05.023"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"34","article-title":"The pioneer who laid the foundation for modern dental research","volume":"68","author":"Ring ME","year":"2002","journal-title":"N Y State Dent J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01425.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/am.24.4.638-644.1972"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.1.59"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/16.Supplement_4.S203"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.53.1.213-220.1986"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.3.716-720.1987"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.5.1795-1802.1991"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120030101"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00002-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120050301"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.8.447"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580120905"},{"issue":"4","key":"e_1_2_8_22_1","first-page":"788","article-title":"\u201cCheckerboard\u201d DNA\u2013DNA hybridization","volume":"17","author":"Socransky SS","year":"1994","journal-title":"Biotechniques"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.2004.00168.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4576"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520949851"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-99014-5_2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3129"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3330"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201900060"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520914594"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/mps6040071"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00841-w"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11427-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2362-2365.2000"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb01272.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701104"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.3.537-542.1996"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.1999.140107.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.12.3770-3783.2001"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01679.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2016.12221037"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146926"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-020-00865-y"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374940080022001"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26082-0"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12065"},{"key":"e_1_2_8_49_1","volume-title":"Oral Biofilms in Health and Disease","author":"Manoil D","year":"2024"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.010"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00575-18"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12362"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13793"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2015.1014266"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090185"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110566"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00729-13"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12190"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baq013"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.49"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12349"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2676"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02374"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13063"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3589"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3319"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3935"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.191"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514542468"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04594-9"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12110687"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514538283"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0153-3"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00886-21"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01012-14"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.23"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13737"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013713905833"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01544-x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.588155"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12351"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00016-17"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15999"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119222"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12096"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-018-0055-4"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091826"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11050590"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac303053e"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2012.02579.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1660-1665.1998"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.07.002"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081581"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512453589"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5410.2095"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519866440"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.774115"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00663.x"},{"issue":"3","key":"e_1_2_8_103_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1099\/00207713-52-3-983","article-title":"Anaeroglobus geminatus gen. nov., sp. nov., a novel member of the family Veillonellaceae","volume":"52","author":"Carlier JP","year":"2002","journal-title":"Int J Syst Evol Microbiol"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3944-3955.2005"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600739"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8020059"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12157"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02000.x"},{"issue":"1","key":"e_1_2_8_109_1","first-page":"1","article-title":"Profiling antibiotic susceptibility among distinct Enterococcus faecalis isolates from dental root canals","volume":"13","author":"Manoil D","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03703.x"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00782.x"},{"issue":"1","key":"e_1_2_8_112_1","first-page":"61","article-title":"Odontogenic bacteria in periodontal disease and resistance patterns to common antibiotics used as treatment and prophylaxis in odontology in Spain","volume":"20","author":"Maestre JR","year":"2007","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.07.004"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13468"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1198-743X.2004.00722.x"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.464"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00925.x"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12034"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.202000011"},{"key":"e_1_2_8_120_1","unstructured":"IAI Institut f\u00fcr Angewandte Immunologie. PadoTest\u00ae.2023.https:\/\/www.institut\u2010iai.ch\/en\/analyses\/padotest\u2010en. Accessed December 15 2023."},{"key":"e_1_2_8_121_1","unstructured":"GENSPEED Biotech. PerioPOC.2023.https:\/\/en.periopoc.com\/. Accessed December 15 2023."},{"key":"e_1_2_8_122_1","unstructured":"OralDNA Labs.MyPerioPath\u00ae Early Warning of Oral Pathogens.2023.https:\/\/www.oraldna.com\/test\/myperiopath\/. Accessed December 15 2023."},{"key":"e_1_2_8_123_1","unstructured":"Direct Diagnostics LLC.HR5\u00ae.2023.https:\/\/www.directdiagnostics.com\/hr5. Accessed December 15 2023."},{"key":"e_1_2_8_124_1","unstructured":"heico Dent GmbH.PCRdent.2023.https:\/\/heicodent.ch\/labor\u2010dres\u2010hauss\/. Accessed December 15 2023."},{"key":"e_1_2_8_125_1","unstructured":"LADR GmbH.Laboratory diagnostics in dentistry.2023.https:\/\/www.ladr.de\/odm. Accessed December 15 2023."},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00285.x"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20205"},{"key":"e_1_2_8_128_1","first-page":"848","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Feres M","year":"2022"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2392-3"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1998.tb02291.x"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00728"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.1.52"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12197"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13164"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130379"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110810"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601105010110"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00462-17"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211035775"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.38.072902.091216"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.22"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090314-050032"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu023"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki008"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-13"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1004"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00483-19"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179834"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38993"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01926-14"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12296"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v5i0.20265"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1832837"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8040222"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.01085-21"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.2.501-508.1994"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1261"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v7.26974"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514526237"},{"key":"e_1_2_8_161_1","unstructured":"IAI Institut f\u00fcr Angewandte Immunologie. PadoBiom\u00ae.2023.https:\/\/www.institut\u2010iai.ch\/en\/analyses\/padobiom\u2010en. Accessed December 15 2023."},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.983991"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12473"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.065441-0"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516648944"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-023-00585-z"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00285-9"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios11110423"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00136.x"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00169.x"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/621484"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0749"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13218"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12234"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1441436"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01600-5"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03281-20"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13617"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2013.4611"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0803"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_2_8_183_1","volume-title":"Oral Biofilms in Health and Disease","author":"Parga A","year":"2024"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-023-00406-3"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12382"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1118630"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2208901"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12363"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-022-11810-8"},{"issue":"2","key":"e_1_2_8_190_1","first-page":"68","article-title":"The specific plaque hypothesis and the antimicrobial treatment of periodontal disease","volume":"19","author":"Loesche WJ","year":"1992","journal-title":"Dent Update"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345540330040301"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(63)90020-7"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(63)90019-0"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1993.tb00312.x"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.108005393.x"},{"issue":"2","key":"e_1_2_8_196_1","first-page":"155","article-title":"Direct examination of subgingival plaque from a diseased periodontal site using confocal laser scanning microscopy (CLSM)","volume":"20","author":"Assmus B","year":"1997","journal-title":"New Microbiol"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.8.2686-2694.1991"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1992.tb00032.x"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-6-r42"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-259"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512449462"},{"key":"e_1_2_8_202_1","first-page":"288","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Schaefer AS","year":"2022"}],"container-title":["Periodontology 2000"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/prd.12571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:39:48Z","timestamp":1725503988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/prd.12571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":201,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/prd.12571"],"URL":"https:\/\/doi.org\/10.1111\/prd.12571","archive":["Portico"],"relation":{},"ISSN":["0906-6713","1600-0757"],"issn-type":[{"value":"0906-6713","type":"print"},{"value":"1600-0757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,26]]},"assertion":[{"value":"2024-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}