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The review specifically focuses on the impact of these treatments on patients' quality of life, pain management, treatment costs, recurrence rates, and potential complications. Given the extensive literature and diverse range of extra\u2010oral wound types in which these autologous platelet concentrates have been applied, this narrative review focuses on the most frequently described wound types, including diabetic foot ulcers, venous leg ulcers, pressure ulcers, surgical wounds, and burns. The use of PRP has been reported in various medical specialties, with a low risk of adverse events. While there is a growing interest in the use of PRGF with promising results, the available literature on this topic is still limited. Only a few studies evaluated patients' perception of the treatment and the relationship between treatment costs and clinical outcomes. Data on recurrence rates and complications also vary across studies. In conclusion, PRP and PRGF show promise as alternatives or as adjunctive therapies to conventional treatments for various extra\u2010oral wounds and ulcers, leading to reduced wound size and accelerated healing time but should be considered on a case\u2010by\u2010case basis, taking into account the type and severity of the wound.<\/jats:p>","DOI":"10.1111\/prd.12572","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:48:30Z","timestamp":1721976510000},"page":"320-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Platelet\u2010rich plasma and plasma rich in growth factors in extra\u2010oral wound care"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-2503","authenticated-orcid":false,"given":"Jeniffer","family":"Perussolo","sequence":"first","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty 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