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How these mechanisms are affected by individual genetics, environmental exposures, and behavioral choices will encompass an expanding role in the future of optimally preventing and treating diseases. Considering saliva as an important biological fluid for analysis to inform oral disease detection\/description continues to expand. This review provides an overview of saliva as a diagnostic fluid and the features of various biomarkers that have been reported. We emphasize the use of salivary biomarkers in periodontitis and transport the reader through extant literature, gaps in knowledge, and a structured approach toward validating and determine the utility of biomarkers in periodontitis. A summation of the findings support the likelihood that a panel of biomarkers including both host molecules and specific microorganisms will be required to most effectively identify risk for early transition to disease, ongoing disease activity, progression, and likelihood of response to standard periodontal therapy. The goals would be to develop predictive algorithms that serve as adjunctive diagnostic tools which provide the clinician and patient important information for making informed clinical decisions.<\/jats:p>","DOI":"10.1111\/prd.12581","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T03:44:22Z","timestamp":1721101462000},"page":"203-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Realizing the clinical utility of saliva for monitoring oral diseases"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-6585","authenticated-orcid":false,"given":"Jeffrey L.","family":"Ebersole","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Dental Medicine University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[{"name":"Immunology and Inflammation, Center for Clinical and Translational Research The ADA Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-8223","authenticated-orcid":false,"given":"Michaell","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gellibolian","sequence":"additional","affiliation":[{"name":"CellectGen, Inc.  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