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APCs contain platelets that release various growth factors with potential applications in facial and dermatologic treatments. This review examines several facial esthetic applications of APCs, including acne scarring, skin rejuvenation, melasma, vitiligo, stretchmarks, peri\u2010orbital rejuvenation, peri\u2010oral rejuvenation, hair regeneration and the volumizing effects of APC gels. A systematic review of literature databases (PubMed\/MEDLINE) was conducted up to October 2023 to identify randomized controlled trials (RCTs) in the English language on APCs for facial rejuvenation and dermatology. A total of 96 articles were selected including those on platelet rich plasma (PRP), plasma\u2010rich in growth factors (PRGF), and platelet\u2010rich fibrin (PRF). Clinical recommendations gained from the reviews are provided. In summary, the use of APCs in facial esthetics is a promising yet relatively recent treatment approach. Overall, the majority of studies have focused on the use of PRP with positive outcomes. Only few studies have compared PRP versus PRF with all demonstrating superior outcomes using PRF. The existing studies have limitations including small sample sizes and lack of standardized assessment criteria. Future research should utilize well\u2010designed RCTs, incorporating appropriate controls, such as split\u2010face comparisons, and standardized protocols for APC usage, including optimal number of sessions, interval between sessions, and objective improvement scores. Nevertheless, the most recent formulations of platelet concentrates offer clinicians an ability to improve various clinical parameters and esthetic concerns.<\/jats:p>","DOI":"10.1111\/prd.12582","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:57:10Z","timestamp":1722477430000},"page":"363-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Autolougous platelet concentrates in esthetic medicine"],"prefix":"10.1111","volume":"97","author":[{"given":"Catherine","family":"Davies","sequence":"first","affiliation":[{"name":"ZD Hair Clinic  Johannesburg South Africa"},{"name":"Advanced PRF Education  Venice Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Advanced PRF Education  Venice Florida USA"},{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007624"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x"},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1454"},{"key":"e_1_2_21_5_1","doi-asserted-by":"crossref","unstructured":"ZhuH HuangZ ShanH ZhangJ.Look globally age locally: face aging with an attention mechanism. 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